14356 results
The aim of this study is to demonstrate which is the most effective operation for neonates with necrotizing enterocolitis (NEC): intestinal resection with stoma formation or intestinal resection with primary anastomosis.
To determine whether fibrinogen concentrate infusion reduces perioperative blood loss and transfusion in patient experiencing clinically relevant microvascular bleeding during elective complex cardiac surgery and to determine whether its use is safe…
To establish the pharmacokinetic profiles of saliva and plasma concentration of 10 mg MPH-IR and 18 mg MPH-OROS in healthy volunteers; to investigate whether there is a correlation between saliva- and plasma levels of MPH-IR and MPH-OROS, and if…
Primary objectiveThe objective of this pilot study is to test the hypothesis that the use of individual head supports will result in an actual given dose to both the target volumes as well as organs at risk that corresponds better to the planned…
To optimize independent functioning and quality of life through:1. Systematic screening for increased risk of functional loss among community dwelling elderly (Phase 1);2. Providing a nurse-led, complex intervention to elderly people with an…
Primary: To find out which areas in the brain play a part in the maintenance of tinnitus, and what the roles of those areas are. This will be done using BOLD response fMRI imaging.Secondary: 1. To find out which areas in the brain play a part in the…
Investigate how S1 and the premotor cortex modulate the cortico-spinal excitability as measures by single pulse TMS stimulation of M1.
Primary:To investigate the safety and tolerability of ascending doses of AZD3514 in patients with metastatic castration resistant prostate cancerSecondary: To assess the pharmacokinetics and preliminary anti-tumour activity of ascending doses of…
Our primary objective is to compare the short term (3 months follow-up) clinical and radiographic results of the Bledsoe Thruster Brace with the SofTec OA Brace in the management of patients with medial knee OA and a varus leg alignment.
The relationship between sleep disorders and (reactive) aggression in forensic psychiatric patients.
The primary objective of this study is to examine the relationship between sleep disorders and (reactive) aggression in forensic psychiatric patients in the Forensic Psychiatric Center Dr. S. van Mesdag in Groningen. In addition to this,…
In this study we aim to validate changes in the pulse pressure after controlled volume loss during blood donation in spontaneously breathing subjects. This validation will contribute to the development of a standardized manner in which the Nexfin…
The primary objective of this study is to examine the difference in VOC pattern of exhaled air (breathprint) between patients with histology-confirmed diagnosis of colorectal cancer and healthy controls. The secondary objectives are to investigate:…
The main objective is to study precision control of trunk posture and associated muscle recruitment in LBP patients and healthy controls during trunk positioning tasks in which postural control is challenged, by increased dead space breathing, by…
The objective of the study is to observe the effect of olanzapineat a dose of 10 mg daily for 14 days when given with/without topiramaat at a dose of 25 and 50 mg twice daily on bodyweight in healthy male subjects. In addition the effect of…
Primary:- to evaluate the safety and tolerability of the compound in different multiple dosing regimens in healthy subjects in different dosing regimensSecondary:- to characterize the pharmacokinetics of multiple oral doses of LY2878735 administered…
Primary:Part I:- to determine the effects of gabapentin and remifentanil on the evoked area of hyperalgesia, area of allodynia, pinprick hyperalgesia and background pain using a newly developed HCW sensitization modelPart II: - to determine…
Primary Objective: To determine the effect of breakfast replacement by a low-glycemic index liquid meal on fasting and postprandial glucose and insulin concentrationsSecondary Objective(s): To determine the effect of breakfast replacement by a low-…
The objective of this pivotal study is to assess the PK and PD as well as safety and tolerability of RP103 compared to Cystagon® in patients with nephropathic cystinosis. Results of this Phase 3 study will be used to support the registration…
Primary objective: To assess the potential effect on QTcF interval (QTc Fridericia) of cabazitaxel in cancer patientsSecondary objectives:• To assess the effects of cabazitaxel on heart rate (HR), QT, QTcB (Bazett*s correction), and QTcN (population…