192 results
The main objective of this study is to investigate the effect of cerebellar tDCS on impulsivity in healthy adults.
To assess the safety, tolerability, biomarker and cognitive efficacy of investigational products in subjects who are known to have an Alzheimer*s disease-causing mutation by determining if treatment with the study drug slows the rate of progression…
To study the effect size of FMT after a 3 weeks course of budesonide as induction therapy in patients with active ulcerative colitis despite previous therapy. The purpose of the pre-treatment is to reduce active inflammation prior to donor feces…
Primary:-To evaluate the efficacy of KEVZARA (sarilumab) in patients with polymyalgia rheumatica (PMR) as assessed by the proportion of subjects with sustained remission for sarilumab with a shorter corticosteroid (CS) tapering regimen as compared…
This study will be performed in 124 healthy male volunteers. The study will be performed in 2 parts, Part A and Part B.Part A will be performed in 64 healthy male volunteers divided over 8 groups of 8 volunteers each.Part B will be performed in 60…
Primary objective: To compare the effect of semaglutide s.c. 2.4 mg once-weekly versus semaglutide placebo as an adjunct to reduced-calorie diet and increased physical activity in subjects with overweight or obesity who have reached target dose of…
To demonstrate whether hydrochlorothiazide or metformin can diminish aquaresis in patients with ADPKD who are treated with tolvaptan as measured by 24-hour urine volume.
The primary objective of this study is to show equivalence of the total pathological complete response rate (tpCR) in patients treated withHD201 plus chemotherapy to that in patients treated with Herceptin® plus chemotherapy. tpCR will be assessed…
Primary Objective:The primary objective of this study is to provide confirmatory data on the beneficial effect of 2.0 g/kg of Octagam 10% given every 4 weeks compared with placebo in subjects with active DM based on the percentage of responders at…
To analyze the difference in fT>MIC at the target site and infection rate for a single dose of 1 and 2g of cefazolin.
The main objective is to demonstrate a significant improvement in self-reported pain after 6 weeks of consumption of eggshell membrane in a typical population suffering from knee osteoarthritis. Secondary, stiffness and performance indices will be…
The primary objective of the proposed study is to evaluate the effect of the high dose or L-arginine (3.0 gram) and a lower dose of L-arginine (1.5 gram) compared with a placebo supplement on postprandial vascular function, assessed by brachial…
Primary objective: To study the safety and tolerability of BIIB078 in adults with C9ORF72-ALS.Secondary objective: To study the pharmacokinetics (PK) profile of BIIB078.
The purpose of this study is to investigate how safe the new compound JHL1922 is when it is administered to healthy subjects. JHL1922 has not been administered to humans before, but it has been previously tested in the laboratory. In this study, the…
To study the effect of TRH on opioid-induced respiratory depression in healthy volunteers.
The main objective of this study is to determine whether creatine monohydrate supplementation enhances diet-induced thermogenesis and brown adipose tissue activity in young, healthy adults, as quantified through PET-MR, following an acute cold…
The primary objective is to evaluate clinically the effectiveness of two oral probiotic strains, compared with a placebo-group, on the gingival health during a two-week wash-in phase followed by a two-week period refraining from oral hygiene and a…
• To determine the profile of CNS effects at several time points after 2 mg and 4 mg biperiden in comparison to placebo in healthy elderly subjects.• To investigate the safety and tolerability of biperiden in healthy elderly subjects.• To determine…
Primary objectives:- improvement of oxygen saturation Secondary objectives:- improvement of quality of life- improvement of exercise capacity- improvement of muscle power- improvement of phase angle- registration of potential short term and long…
This study will evaluate the safety, efficacy, and pharmacokinetics of UTTR1147A compared with placebo and compared with vedolizumab in patients with moderate to severe ulcerative colitis (UC).