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Randomised, double-blind, sequential-group, placebo-controlled, single-ascending oral dose, interventional study, investigating the safety, tolerability, pharmacokinetics, pharmacodynamics and metabolite profile of Lu AF09535 in healthy young men, and an open-label crossover to study intra-subject variability and effects of food

- to examine the safety and tolerability of the research medication- to examine how the research medication is absorbed, broken down and excreted by the body.

A randomized controlled trial to asses the effect of vitamin D in patients with atopic dermatitis.

The main study objective is to determine the time to, as well as number of exacerbations of atopic dermatitis in the study period between the study groups A and B. The secondary objectives are the differences in transepidermal water loss and Quality…

An Open-label Randomized Phase III Trial of BMS-936558 versus Docetaxel in Previously Treated Advanced or Metastatic Squamous Cell Non-small Cell Lung Cancer (NSCLC)

Primary ObjectiveTo compare the objective response rate and overall surival of BMS-936558 versus docetaxel in subjects with squamous cell NSCLC after failure of prior platinum-based chemotherapySecondary ObjectivesTo compare the progression-free…

A study to compare the efficacy and safety of once daily QVA149 vs. the once daily concurrent administration of QAB149 plus NVA237 in patients with moderate to severe chronic obstructive pulmonary disease (CQVA149A2326)

Primary objective: To evaluate the non-inferiority of QVA149 110/50 µg qd as compared to concurrentadministration of QAB149 150 µg qd plus NVA237 50 µg qd in terms of its effect on trough FEV1 (mean of 23 h 15 min and 23 h 45 min post-dose)…

A PROSPECTIVE, MULTINATIONAL, OPEN-LABEL, SINGLE-ARM, EXPLORATIVE STUDY TO EVALUATE THE TOLERABILITY AND EFFICACY OF LACOSAMIDE WHEN ADDED TO LEVETIRACETAM WITH WITHDRAWAL OF THE CONCOMITANT SODIUM CHANNEL BLOCKING ANTIEPILEPTIC DRUG IN SUBJECTS WITH UNCONTROLLED PARTIAL-ONSET SEIZURES

The primary objective of this study is to assess the overall effectiveness of LCM (optimizedwithin the range of 200mg/day to 600mg/day) when added to a stable dose of LEV (in thelabel range of 1000mg/day to 3000mg/day) with withdrawal of the…

The effect of a gastric bypass operation on family members

Primary objective:To observe the effect of gastric bypass surgery on household members and partners who live together with the patient on body mass index (measured as weight/height²) in the first year following bariatric surgery compared to family…

Late effects of radiotherapy in patients with optic nerve sheath meningioma

Assessment of late effects of radiotherapy in patients with ONSM.

A Phase 2 Study of LY2157299 Monohydrate Monotherapy or LY2157299 Monohydrate plus Lomustine Therapy compared to Lomustine Monotherapy in Patients with Recurrent Glioblastoma

The primary objective of this study is to compare the overall survival (OS) distributions between LY2157299 monohydrate plus lomustine therapy with lomustine plus placebo therapy (control arm), in patients who have relapsed or have progressive GB…

ACURATE TA* Transapical Aortic Bioprosthesis for Implantation in Patients with Severe Aortic Stenosis

Primary: To evaluate the safety of the study device in patients presenting with severe aortic stenosis (AS) considered to be high risk for surgery.Secondary: To evaluate adverse events and study device performance.

RAndomized comParison between the STENTYS self-aPpOSIng Sirolimus-eluting Coronary STent and a balloon-expandable stent In AcuTe MyocardIal InfarctiON

The objective of this study is to evaluate whether two different stent technologies (a self-expandable stent and a balloon-expandable stent) may be associated with different stent strut apposition and a variety of stent strut coverage with…

A SINGLE-CENTER, OPEN-LABEL, ONE-SEQUENCE, THREE-PERIOD CROSSOVER STUDY TO EVALUATE THE PHARMACOKINETICS OF HP-3040 PATCHES (TOLTERODINE TRANSDERMAL DRUG DELIVERY SYSTEM) FOLLOWING 168-HR APPLICATION COMPARED TO SINGLE-DOSE DETROL® LA 2 MG (TOLTERODINE TARTRATE EXTENDED RELEASE CAPSULE) IN HEALTHY ADULT MALE SUBJECTS

The purpose of the study is to investigate how quickly and to what extent tolterodine is absorbed and eliminated from the body (this is called pharmacokinetics) when it is administrated by using a HP-3040 transdermal patch. Moreover, the relative…

The effect of liraglutide versus placebo when added to basal insulin analogues with or without metformin in subjects with type 2 diabetes
A 26-week double-blind placebo-controlled randomised multicentre, multinational
parallel-group trial

To confirm superiority on glycaemic control of liraglutide versus placebo after 26 weeks of treatment when added to pre-existing basal insulin analogue treatment (with or without concomitant metformin treatment) in subjects with type 2 diabetes.

Intravenous Access during Resuscitation

To compare the effects of central versus peripheral drug administration on the rate of return of organised electrical activity and/or spontaneous circulation during CPR.

Validation of driving-related psychometric tests to predict performance on a standard on-the-road test after prolonged wakefulness.

The aim of the study is to determine which computer tests can be used best to measure changes in driving ability.

An open label, part-randomised, four-way crossover, single and repeat dose study to determine the dose proportionality and absolute bioavailability of fluticasone furoate (FF) when administered as FF inhalation powder from the novel dry powder inhaler in healthy subjects.

The purpose of the study is to investigate to what extent blood concentrations of Fluticasone Furoate increase proportionately to rising doses of Fluticasone Furoate in three steps administered via a powder inhalator. In addition, the absolute…

Long term follow-up of anterior cruciate ligament ruptures: bone-patellatendon-bone autograft reconstruction versus non-operative treatment.

To study the clinical and radiological outcomes 20 years after operative or conservative treatment for an ACL rupture

Prehospital fascia iliaca compartment block

Can paramedics safely and effictively perform the FIC block prehospitally?

Pulmonary Rehabilitation of Asthma: a Trial of sustained Internet based Self-management Support)

To assess the one-year (cost)effectiveness of self-management support via an internet-based service in addition to usual care as compared to usual care alone in a pragmatic trial in patients with severe asthma who are referred for a pulmonary…

Reasons for exclusion prenatale diagnosis or preimplantation genetic diagnosis in Huntington disease

This study aims to get insight in reasons and motives of couples who choose for exclusion prenatal or preimplantation genetic testing. We will explore experiences of these couples in order to give recommendations for counseling of future couples.…

The effect of additional foot support with or without seat surface forward tilting on upper extremity function in children with spastic cerebral palsy*

To evaluate the effect of additional foot support during sitting and the effect of forward tilting of the seat surface on 1) postural adjustments during reaching and 2) the quality of reaching movement in school age children with CP.