408 results
Primary objective To evaluate the Overall Response Rate (CR/PRrate) in patients treated with pembrolizumab for recurrent or progressive PCNSL after MTX-based first-line therapy To evaluate the safety of pembrolizumab in subjects diagnosed with…
To investigate if patient controlled sublingual sufentanil tablets as compared to patient controlled intravenous morphine lead to improved independent mobilization on postoperative day 1 after laparoscopic donor nephrectomy (LDN).
Safety:* Evaluate the safety of AVXS-101 through incidence of adverse events (AEs) and/or serious adverse events (SAEs)* Evaluate the safety of AVXS-101 based on the change from baseline in clinical laboratory parametersEfficacy objectives will be…
Primary: to determine if inhibition with GPB can provide a significant (>30%) reduction in the accumulation of orally administered Iodine-123 in salivary glands, measured at 4h after administraion. Secondary: to determine if a reduction at 4h…
The collection of data of the orofacial motor skills with the OMOK in healthy children between 2 and 8 years.
We aim to prevent or reverse developmental regression in patients with Kleefstra syndrome. We hypothesise that the regression we observed is the result of a psychotic disorder, which isnot properly recognised by clinicians and often not treated…
To determine the efficacy of a filter-based depletion of RBC-pathogen complexes by a single apheresis tretatment in patients with sepsis.
To investigate if a personalized dietary advice is more effective in increasing dietary fiber intake in the Dutch population than the general advice that is currently provided by the Netherlands Nutrition center and the Dutch Digestive Foundation (…
The primary objective of this study is to describe the long-term safety of dupilumab in the treatment of patients with moderate to severe asthma who completed the previous asthma clinical trial, TRAVERSE-LTS12551.
To assess the feasibility of real-time MRI temperature monitoring and ablation zone assessment during thermal ablation of liver tumours.
The objective of this study is to investigate the feasibility of treating breast and lung cancerpatients in mDIBH using nasal a high-flow therapy (NHFT) device.
To evaluate the effectiveness of eccentric calf muscle exercise therapy compared to strength training of the upper extremities (control group) in patients with chronic midportion Achilles tendinopathy.
- To study the success rate of organoid culture from lymph node, visceral and bone metastases in metastasized urogenital cancer and examine which parameters influence the success rate (culture media, biopsy site, cell counts). - To study the…
To quantify clinical and histological changes of the skin in promoting early wound healing when SVF + PRP injectable is used as treatment in comparison to SVF and PRP alone.
Objective: The primary objective of this study is to evaluate the pharmacokinetics of midazolam in elderly patients (>70 years) admitted to the ICU.
To investigate the effect of new hearing aid processing techniques on speech understanding and sound localization in bimodal listeners
Objective: The primary objective is to examine whether EMDR therapy has mood-stabilizing effects in traumatized patients with mild depressive and/or manic symptoms. The secondary objective is to examine the hypothesis that EMDR is an effective and…
The main study objective will be to determine whether a newly developed rehabilitation protocol is non-inferior to the current rehabilitation protocol - golden standard - used after ACL reconstruction.
The primary objective of this study is the further evaluation and optimization of skeletal muscle tissue and MRI biomarkers for a planned POC study of FTX-1821 in FSHD. Therefore, this study is not a drug trial but rather a preparatory biomarker…
To ascertain the amount of UV-damage (p53 activation, apoptosis, thymidine dimers and γH2AX) is caused by the Dermasun treatment in psoriasis patients.Total skin check in patients using Dermasun for a prolonged period of time to screen for (pre-)…