78 results
The primary objective is to compare the effectiveness of ambroxol versus placebo on the MDS-UPDRS part III motor sub-score in the *practically defined OFF-medication state* in patients with moderate PD, carrying a GBA mutation. The hypothesis is…
This study is aimed at investigating the effect of imagery rescripting on selfreported low self-esteem in personality disorders and the effect on diverse complaints (anxiety, depression), wellbeing and core cognitions. This might be a step into…
The objective of this clinical study is to assess the safety and effectiveness of the Apollo Intravascular Lithotripsy (IVL) System for lithotripsy-enhanced balloon dilatation of calcified, stenotic de novo coronary lesions prior to stenting.The…
The VOLT AF First-in-Human (FIH) study will collect feasibility data to show that the Volt PFA System functions as intended in a clinical setting and to demonstrate acute safety and effectiveness for the treatment of symptomatic, recurrent…
To assess the safety of a novel care pathway in which patients, with a predicted mild course of acute pancreatitis, are discharged early with remote home monitoring.
The purpose of this study is the evaluation of InPen* with InPen* 2.0 app and Guardian* 4 system in adult patients with type 1 diabetes for the design of a future study.
To collect safety and efficacy data from study participants that have been treated with the miraDry System using High Volume Anesthesia (HVA, also known as LTA or Local Tumescent Anesthesia) method as the local anesthesia delivery method.
The aim of the proposed study is to describe in older adults the incidence of respiratory viral infections and to gain better insight into the nasal mucosa and mucosal and systemic immune responses in older adults in the absence and presence of a…
The main objective of this study is to assess patient reported outcome measures of adult patients who are diagnosed with a distal radius fracture and treated with a patient-specific 3D- printed splints as compared to a control cohort.
Objective of the quantitative and qualitative study:To gain knowledge about which transdiagnostic factors are associated with dropout from and outcome of intensive high-specialty treatment.Objective of the pilot study:To gain insight into the role…
This study is performed to investigate the optimal strategy for maintaining quality of life and improving survival in elderly patients (65 years or older) diagnosed with primary GBM. Primary endpoints of the study are: 1) Proportion of patients with…
In this multicenter prospective cohort study we will investigate the feasibility of TE-ST.
The aim of this study is to improve the conservative management of OCLs of the talus in the skeletally immature due to the comparison of two different conservative strategies. An optimal conservative treatment can result in a better quality of life…
Primary objective:-To confirm that the Event-Free Survival (EFS) in patients >= 3 years of age with WHO grade IV/CNS WHO grade 4 and WHO grade III/CNS WHOgrade 3 diffuse high grade gliomas as well as diffuse high grade gliomas without a…
We aim to investigate whether sodium oxybate can be used as a novel treatment in psychiatric patients with catatonia. Our primary objective is: To determine if sodium oxybate is effective as a novel treatment in psychiatric patients with catatonia…
The objective of the HORIZON trial is to demonstrate and provide long-term clinical data on safety and performance of the Qmedics EXIST NiTi Stent System type FLEX & PULL for treating de novo or re-stenotic symptomatic atherosclerotic…
The aim of the present study is to assess whether the postprandial glucose response of the new test products is superior to the postprandial glucose response of an original treatment option.
Primary Objective: The feasibility of injecting 99mTc-nanocolloid via a flexible laryngoscope with a working channel and subsequent detection of SLN will be evaluated.Secondary Objective: Preoperative located SLN via gamma camera imaging will be…
To compare the efficacy of PPS above the ampulla to standard EBD in patients with MHBO who are ineligible for surgical resection.
The primary question in this study is: what is the weight development for adolescents with an eating disorder during FBT? The secondary objectives are about the course of eating disorder symptomatology, as well as anxiety and mood complaints. And in…