199 results
PrimaryEffective treatment regimes and preventive tools of SIB in CdLS by studying phenomenology, etiology and pathogenesis.Secondary a. Development of a flow chart for daily care (diagnostics; management) b. Evaluation whether the present study can…
Assessment of glucose homeostasis and pancreas size (MRI) in 10 subjects with heterozygous mutations in EXT-1, in 10 subjects with heterozygous mutations in EXT-2 and 10 unaffected related controls as well as 10 subjects with known type 2 diabetes…
1. the primary objective of this study is to examen the incidence and prevalence of PTSDand depression in pre-eclampsia patients after delivery2. a secondary objective is to identify risk factors during pregnancy, durante partu and postpartum…
The aim of this research is, following the aforementioned theoretical framework, to investigate whether the two candidate genes in combination with EEG and fMRI markers differentiate between children that do and do not show a clinical response to…
To assess whether bile acids reach the brain after a meal
The aim of our study is to measure 1) the prevalence of signs of child abuse and neglect in children with functional defecation disorders, 2) whether signs of child abuse and neglect are more common in children with functional defecation disorders…
Here we propose that in order to identify causal mechanisms that explain AD/HD-related heterogeneity, an integrative approach is needed. Therefore, in this project we will study the interaction between motivation and executive function in AD/HD and…
Primary: to study the frequency and characteristics of fatigue and cognitive disorders after minor stroke. Secondary: to gain more insight in the aetiology of post-stroke fatigue and evaluate the impact of post-stroke fatigue on personal and social…
The primary objective is to establish the point prevalence of Airflow Limitation (AL) compatible with COPD in patients with congestive heart failure (CHF) seen in a single centre in the Netherlands.
The primary objectives of our study are:1. to compare the diagnostic performance of coronary CTA with coronary MRA to detect significant coronary stenoses (> 50% reduction in lumen diameter), in patients with a range of coronary calcium…
The aim of this pilot study is to assess whether the cerebral metabolic changes in RA patients, are also present in CD patients with active disease and fatigue. The influence of chronic inflammation on cerebral metabolism in CD patients will be…
The aim of the present study is to identify aberrations that play a significant role in therapy response of ovarian cancer patients. RNA sequence/expression and protein expression data will be combined and correlated to the extensive clinical follow…
The research aims to identify avoidable and non-preventable factors, which contribute to the development of chronic tophaceous gout. In addition, the study aims to assess the consequences (quality of life, comorbidity) of tophi.
Our primary objective is to visualize the vascular involvement in the pathogenesis of psoriasis with the TOPCam. In particular we asked the following questions:(i) Can the TOPCam image the structure of vascular changes in the clinical lesions?(ii)…
2. OBJECTIVESPrimary Objective: 1. Does conversion tremor show similar abnormal cerebral activation patterns compared to conversion pareses?Secondary Objective:1. Is decreased precuneus activity also present in conversion tremor?
To investigate the effects of lowered physical activity (resulting in decreased muscle mitochondrial oxidative capacity) together with increased plasma free fatty acid availability (by infusion of a clinically widely used lipid emulsion (Intralipid…
The aim of the study is to investigate the effect of statins on ery-apoB levels.
Aim of the present study is to characterize esophageal epithelial damage in NERD, EE and healthy controls by analysis of epithelial integrity, immunohistochemical markers of epithelial damage and histological changes of esophageal epithelium.
The main goal of this project is the elucidation of the mechanism underlying the paternal inheritance seen in SDHD- and SDHAF2-related paraganglioma. The results of this project should aid us in the identification of the *modifier* gene, essential…
To further investigate the pathogenesis of DCI and its relation to gender, decreased fibrinolysis, increased coagulation, and hormonal factors in order to eventually pave the way for new treatment options.