481 results
The AMSTAD-OCD study aims to contribute to the improvement of outcome in OCD by identifying the determinants of a chronic course.
Primary Objective:Delineate the differences in cellular composition and function at the maternal-fetal interface in patients with SLE compared to healthy women Secondary Objectives:- Establish a novel in-vitro model to study cell-cell interaction at…
The main study objective is to examine the effect of the PTWD program on glycaemic control of lower-educated participants with T2D. The secondary objectives include the effect on medication use, use of care and T2D self-management behaviours. We…
1. To evaluate the efficacy of a gait training program using an instrumented treadmill with virtual and augmented reality for improving gait adaptability in people in the chronic phase after stroke in an RCT. 2. To identify patient characteristics…
In this study we will confirm that a microbial intervention based on capsules containing autologous (own) lyophilized faecal matter (LFMT), taken daily for 3 month has beneficial effects on residual beta cell function (C-peptide secretion upon MMT)…
The aim of this study is to determine functional parameters of the maternal heart during the lactation period by echocardiography and to correlate these functional parameters with circulating hormones.
The aim of this study is to determine NET availability in patients with neurodegenerative diseases to characterize NA system degeneration in people with Alzheimer's disease, Parkinson's disease (with and without dementia) and with…
The primary objective of this study is to establish the relationships between structural and neural adaptation of human skeletal muscle when muscles are exposed to overstretch and overload through exercise.
The primary objective of this study is to validate the prediction model on the effect of a standardized mixed meal challenge on postprandial triglyceride levels in a heterogenous group of middle-aged, overweight to obese individuals. The secondary…
1. To determine the prevalence of cam morphology in a sample of professional female football players.2. To determine the prevalence of other hip related radiological features (e.g. neck-shaft angle, epiphyseal extension, lateral centre edge angle…
The primary objective in this trial is to evaluate the use of MRI and contrast enhanced mammography after using MagTrace® to perform a breast conserving surgery and a sentinel node biopsy.
Part 1:Primary Objective- To investigate whether repeated dose GRX-917 reduces panic symptoms elicited by an experimental 35% CO2 -induced fear challenge administered in healthy CO2-sensitive subjects. Secondary Objectives- To investigate whether…
Assess amyloid beta clearance from CSF to serum in response to HFCWO in healthy volunteers:- Change from baseline in amyloid beta 40 (ng/ml) in CSFAssess endogenous protein biomarker clearance from CSF to serum in response to HFCWO in healthy…
3. STUDY OBJECTIVES3.1. Primary ObjectivesThe primary objectives are:• To determine if CAEL-101 and treatment for PCD improves overall survival in Mayo stage IIIa AL amyloidosis patients who are treatment naïve compared to treatment for PCD alone•…
The main objective is to determine function/clinical outcome, measured by the NRS-11 score for pain, 3 months after intervention and compare this between the surgery and conservative group. Secondary objectives are functional outcome as measured by…
The primary objective of this study is to assess if GUD is associated with increased oxidative stress and/or inflammatory markers in the blood. The secondary objectives of this study are to assess whether GUD is associated with decreased working…
Primary Objective: 1. To determine the effectiveness of a personalised, holistic 24-week digital lifestyle programme in achieving diabetes type 2 (T2DM) remission independence from blood glucose-lowering medications, in a Dutch population, in…
Objectives: The immunogenic effects of adrenal SMART schemes may vary even though the local tumor control rates are high. Our objective is to study the dose-related immunological signals accompanying the delivery of SMART to adrenal metastases using…
The main objective of this study is to assess the effect of GOS in combination with 2*-FL on perceived stress. The secondary objective is to assess the effect of GOS in combination with 2-FL on saliva cortisol levels, as well as on perceived anxiety…
Primary objective of the study is to compare the readings of the different sample types (venous whole blood, plasma and capillary) for the three different analytes (BNP / NT-proBNP / D-dimer) on the Atellica VTLi system, according to CLSI EP09c…