36 results
Primary Objectives:- Determine the effect of pulmonary vasodilatation on indexed cardiac output during simulated exercise.- Characterization of structural properties of small pulmonary arteries.Secondary Objectives: - Investigate the effect of…
The aim of this study is to assess differences between lean and morbidly obese subjects in gut permeability, gut microbiota and mucosal inflammation and to assess the effects of weight loss after sleeve gastrectomy on gut permeability, microbiota…
Immunodetection of Thyrothrophin (TSH) receptor in myometrium tissue.Furtermore the aim is to test myometrium tissue in vitro for it's relaxation and contractility and it's conductance of electropotentials.
To obtain insight in the role of the innate immune response, especially Type 1 interferons, in the pathogenesis of RSV LRTI. New techniques are used to unravel the local (nasopharyngeal) immunological milieu during viral LRTI. The hypothesis is that…
Using electroencephalography to relate behavioural research on Autism Spectrum Disorder (ASD) to electrophysiological findings.
The main objective of this study is to analyse the effect of fetal sex on levels of T and macrophage cell subsets in decidual tissue. Secondary objectives will be to analyse differences in the effect of maternal blood stimulation by fetal leukocytes…
- Examine the reproducibility of the non-volitional endurance test in healthy subjects. The hypothesis is that the non-volitional endurance test is reproducible.- Comparing arm and leg muscle endurance in healthy subjects. It is expected that arm…
Primary Objective: To assess the differences between lean and obese subjects in tissue PYY and GLP-1 levels and gene activity, and in L-cellular secretion before and directly after nutrient exposure. Secondary Objective: To correlate these…
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The main question in the study isHow do moderately preterm infants and their parents differ from term, as well as extreme preterm infants in (a) development and self regulation skills of the infants, (b) interaction patterns and relationship between…
The primary objective of this study is to define differences in the inflammatory response, coagulation, and fibrinolysis in CABG patients with either MECC or conventional CPB.
To determine the incidence and grade of venous emboli and/or paradoxical gas emboli during hysteroscopy surgery using TOE. In addition, a comparison will be made using either bipolar or monopolar diathermia. Knowing the incidence and severity of…
Using the model of lipid-induced insulin resistance we will study the hypothesis that pre-treatment with salsalate (salicylsalicylic acid) blunts the development of lipid-induced insulin resistant in an I*B/NF*B dependent manner in healthy human…
Primary: Investigate if sterile transparent dressing pasted on the skin before CVC insertion reduces the contamination risk of the CVC.Secondary: Investigate if direct contamination has a clinical significance.Investigate what the mayor…
Determination of possible risk factors for developing osteoporosis in GOLD II COPD patients.
The primary goal of this research is to characterize the regulatory Treg population in peripheral blood and bronchoalveolar lavage in patients with sarcoidosis compared to healthy controls. What is the frequency of these cells, what is the phenetype…
(1) To examine the adherence to the prevention and PCI guidelines and the effects thereof on long term prognosis in PCI patients. (2) To evaluate the effectiveness of the psychosocial screening instrument of the European Society of Cardiology…
(I) Investigating the role of the cholinergic system and CBGTC-loop in the pathophysiology of CD, related to both motor and NMS; (II) Finding a biomarker for DBS efficacy in CD, including motor and NMS.
Unravelling the biopsychosocial factors of fatigue and sleep complaints after traumatic brain injury
Examining the development of fatigue and sleep complaints following moderate to severe TBI and exploring the underlying causes within a biopsychosocial model. We hypothesize that biological factors are associated with sleep complaints and fatigue in…
Objective: As we have to integrate information on genetics, immune cells and microbes, a panel of biomaterials (isolated from blood, stool and gastrointestinal mucosal biopsies) will be sampled. From these samples genomic, transcriptomic,…