Search for a trial

The role of innate immunity in the pathogenesis of acute respiratory syncytial virus lower respiratory tract infection:
Repeated measurements of nasopharyngeal type 1 interferon levels in RSV infections

To obtain insight in the role of the innate immune response, especially Type 1 interferons, in the pathogenesis of RSV LRTI. New techniques are used to unravel the local (nasopharyngeal) immunological milieu during viral LRTI. The hypothesis is that…

6 months Evaluation of the BIOTRONIK CoCr PRO-Kinetic Coronary Stent System in patients with single de Novo lesions in Native Coronary Arteries

The primary objective of this study is to evaluate safety and efficacy of the BIOTRONIK PRO-Kinetic coronary CoCr-stent in patients with single de novo lesions of native coronary arteries.

Autologous Platelet-Leukocyte Gel Therapy during sternum closure in cardiac surgery patients at risk for post-operative infection.

To investigate whether application of APLG will lead to reduction in: 1) sternal wound infections 2) vessel harvest site infections 3) postoperative blood loss 4) postoperative pain

Effect of endoscopic treatments of Barrett's oesophagus on oesophageal motility and reflux

To compare oesophageal motility as well as refluxcharacteristics before and after endoscopic treatment of the Barrett segment, and to study differences between patients treated with SRER or BÂRRx.

Home treatment of patients with pulmonary embolism based on pro-BNP levels

The aim of this study is to investigate the safety of treatment of PE in an outpatient setting based on normal pro-BNP levels. The mortality rate and the incidence of hemodynamic instability as well as major bleeding and recurrent VTE in the…

The application of autologous platelet rich fibrin reduces allogeneic blood transfusions and improves wound healing in total hip arthroplasty

The primary objective of this study is to investigate whether application of PRF® will reduce postoperative wound leakage, the necessity for allogeneic blood transfusions and the incidence of wound healing disturbances in patients undergoing…

Hemodynamic measurements and vessel wall property assessment in patients with abdominal aortic aneurysm during pre-operative dynamic MRI examinination.

To assess the influence of bloodpressure, wall thickness, wall properties, and geometry changes throughout the cardiac cycle on the wall stress calculations. Previous analysis were performed with an assumed bloodpressure value, an uniform wall…

Quantitative and qualitative determination of natural occuring regulatory t cells in blood and bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis and healthy volunteers.

The primary goal of this research is to characterize the regulatory Treg population in peripheral blood and bronchoalveolar lavage in patients with sarcoidosis compared to healthy controls. What is the frequency of these cells, what is the phenetype…

Long-term cardio- and neurovascular effects of radiotherapy and chemotherapy in patients with Hodgkin's lymphoma

The main objectives are :Cross-sectional:1. To investigate the extent of atherosclerotic disease of the carotid artery defined as: (a) the intima-media thickness (IMT) (b) the elasticity (c) the degree of stenosis2. To define the degree of…

Effect of Clopidogrel (Plavix) on Postoperative Bleeding in Patients undergoing Coronary Artery Bypass Surgery. A prospective randomized controlled study.

To investigate if the interruption of the clopidogrel is necessary before CABG in order to prevent bleeding and other complications, and if so, which is the safe time interval to proceed with surgery. To asses the predictive value of the TEG clot…

Insertion of a central venous catheter through a tegaderm as a preventive measure against catheter colonization and infection

Primary: Investigate if sterile transparent dressing pasted on the skin before CVC insertion reduces the contamination risk of the CVC.Secondary: Investigate if direct contamination has a clinical significance.Investigate what the mayor…