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A multicenter randomized controlled trial comparing long term scar quality after hydrosurgical versus conventional tangential excision of deep dermal burns

To assess and compare long term scar quality of deep dermal burns after debridement with hydrosurgical- and conventional tangential excision.

A phase I, randomised, double-blind, placebo-controlled study in patients with amyotrophic lateral sclerosis to further assess the safety and tolerability of intracerebroventricular administration of sNN0029 infusion solution.

The objective of the trial is to assess the safety and tolerability of i.c.v. administration of sNN0029 infusion solution at a dose of 4 µg per day delivered via a Medtronic SynchroMed® II Infusion System.

The effect of cognitive bias modification of interpretive bias in the treatment of dental phobia

Investigation of the effect of interpretive bias modification on anxiety levels in dental phobia. If CBM-I indeed has positive effects in the treatment of dental phobia, it could be integrated in the treatment-as-usual as an additional intervention…

Spinal cord stimulation for treating diabetic neuropathic pain; a validation study

To validate the results from two RCTs that SCS is indeed capable of treating otherwise refractory diabetic neuropathic pain, and to evaluate the effects of burst stimulation settings in this patient group.

Characterization of Methylation Patterns in Lung Cancer (Lung-RND-001)

• Characterization of methylation patterns in blood samples and finding of methylation patterns that are unique to lung cancer.• Development of a molecular test for early diagnosis of lung cancer from a blood sample that will be more sensitive and…

The effect of hypnotherapy on exercise-induced asthma in children

Primary Objective: • To assess the protective effect of hypnotherapy training on asthma control (measured with the fall in FEV1 after an ECT ) in children with EIB between 8-18 years. Secondary Objectives: • To assess the protective effect of…

The Dutch Parkinson and Cognition Study (DUPARC):
A prospective study on cognitive pathology in de novo Parkinson*s disease

The primary objective is to establish the relationship between cognitive impairment and cholinergic neurodegeneration in de novo PD patients, by studying cholinergic imaging using [18F]Fluoroethoxy-Benzovesamicol ([18F]FEOBV) PET and…

Unravelling the biopsychosocial factors of fatigue and sleep complaints after traumatic brain injury

Examining the development of fatigue and sleep complaints following moderate to severe TBI and exploring the underlying causes within a biopsychosocial model. We hypothesize that biological factors are associated with sleep complaints and fatigue in…

Carfilzomib, Lenalidomide and Dexamethasone versus Lenalidomide and Dexamethasone in High- Risk Smoldering Multiple Myeloma: A Randomized Phase 2 Study

The primary objective of the study is :To assess MRD negativity rate by NGF after 9 cycles for all eligible ITT patients of KRd versus Rd in patients with high-risk SMMSecondary objectives:• To assess MRD (NGF) negativity rate after 4 cycles of…

instantaneous wave-free ratio guided multi-vessel revascularization during percutaneous coronary intervention for acute myocardial infarction

The iMODERN trial will compare iFR-guided revascularization of noninfarct lesions during acute intervention with a stress perfusion CMR-guided strategy during the outpatient follow-up, to determine the optimal therapeutic approach for STEMI patients…

A Phase 3, Randomized, Double-Blind, Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Subjects with Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Non-Biologic Disease Modifying Anti-Rheumatic Drug (DMARD) - SELECT - PsA 1

This is a Phase 3 multicenter study that includes two periods. Period 1 is designed to compare the safety, tolerability, and efficacy of upadacitinib low dose once daily (QD) and high dose B QD versus placebo and versus adalimumab every other week (…