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A study to evaluate the response of whole blood stimulation with lipopolysaccharide or other inducers and its in vitro inhibition in healthy volunteers, and patients with a chronic inflammatory condition

At CHDR, experience has been gained with the assessment of the in vitro inhibition by MAP kinases of the LPS-induced TNFα release in healthy male volunteers. However, relatively little is known on the inhibition by MAP-kinases in other populations.…

Registry of the treatment of primary insufficiency of the great saphenous vein with a diameter >/= 12 mm, antero-lateral branches, or great saphenous vein insufficiency below the knee with mechano-chemical endovenous ablation (MOCA)

The goal of this registry study is to provide insight in the safety and efficacy of treatment with MOCA for primary insufficiency of the GSV with a diameter >/=12mm, insufficient antero-lateral branches (<12 mm) and insifficincy of the…

PreCARA: Preconception Counselling in Active Rheumatoid Artritis and other chronic inflammatory arthritides;
Preconception counselling for women with rheumatoid arthritis (RA) or another chronic inflammatory arthritis and a pregnancy wish, which is evaluated in a prospective observational study monitoring pregnancy, delivery, postpartum period of the mother, and (growth) parameters of the child.

In the present study we will evaluate the standardized care protocol developed in our outpatient clinic, intended to guide counselling for medication use prior to pregnancy. This protocol guides treatment decisions based on disease activity,…

The long-term follow-up interferon-α treatment for chronic hepatitis B infection

To study the long-term effects of interferon-α treatment for chronic hepatitis B patients infection.

Intrathoracic versus Cervical ANastomosis after minimally invasive esophagectomy for esophageal cancer: a randomized controlled trial

The ICAN research question is: What is the effectiveness of an intrathoracic compared to a cervical esophagogastric anastomosis after (hybrid) minimally invasive esophagectomy in terms of anastomotic leakage, morbidity, quality of life and costs?

Breast conserving therapy using Accelerated Partial Breast Irradiation (APBI) in elderly patients: a feasibility study

Confirm favorable treatment results of international studies.Relate (loco regional) tumor control, side effects and (inter current) death to geriatric questionnaires/condition, co-morbidity and usage of medication.

Surgical Replacement and Transcatheter Aortic Valve Implantation Trial 10 Year Follow-up

The objective of this trial is to characterize annually the safety and durability data through 10 years in a subset of subjects randomized in the SURTAVI trial.

The effect of oral ingestion of casein protein versus whey protein on plasma amino acids, satiety and anorexigenic hormones after gastric bypass surgery

To investigate whether a test meal in gastric bypass patients with supplemented casein protein results in higher concentrations of satiety-related plasma amino acids and satiety-related hormones and leads to more postprandial satiety and less hunger…

Open-Label, Multi-Center, Randomized Study of Anti-CCR4 Monoclonal Antibody KW 0761 (mogamulizumab) Versus Vorinostat in Subjects with Previously Treated Cutaneous T-Cell Lymphoma (CTCL)

The main purpose of this study is to determine if KW-0761, an investigational drug will work against cutaneous T-cell lymphoma (CTCL) that has failed to respond to other treatments, and to evaluate its side effects. An investigational drug is one…

Prospective comparative study between Deflux® and Vantris® for endoscopic treatment of vesico-ureteral reflux in children.

Primary Objective: The treatment result expressed as the proportion of successful treatments per treatment arm (successful = VUR <= grade 1 and/or no urinary-tract infections 6 months after the operation) does at least not show a significant…

The effect of rectus femoris transfer on stroke survivors walking with a stiff knee gait.

Determine the effect of rectus femoris transfer on stroke survivors walking with a stiff knee gait on functional-, activity- and participation level.

The effectiveness of an Oscillating Positive Expiratory Pressure (OPEP) Therapy on respiratory symptoms in patients with COPD/chronic bronchitis with excess mucus in daily clinical practice

To evaluate the effect of OPEP use on respiratory symptoms in patients with COPD or chronic bronchitis with excess mucus in daily clinical practice.

Care4Stroke+ program: Caregiver mediated exercises with e-health support for early supported discharge after acquired brain injury.

The primary aim of this study is to evaluate the feasibility, clinical effectiveness and cost effectiveness of a caregiver mediated exercises programme combined with e-health services (CARE4STROKE+) to improve self-reported health status and reduce…

The efficacy of pharmacological treatment of overactive bladder symptoms, evaluated by the PelFIs questionnaire.

Main objective: To evaluate the outcomes of the PelFIs in patients with OAB; the relation to the clinical efficacy of antimuscarinic treatment and to hyperactivity of the pelvic floor muscles.Secondary objectives:• To asses the efficacy of…

Double-blind randomised placebo-controlled cross-over study to investigate the effectiveness of intramuscular magnesium on pain and dystonia in Complex Regional Pain Syndrome type 1

Primary aim of the study is to evaluate the efficacy and safety of intramuscular magnesiumsulphate in CRPS I patients during 3 weeks dose escalation study.

Botulinum toxin as a new treatment modality for jerky psychogenic movement disorders: a monocenter randomized controlled trial

To evaluate the effect of treatment with BoNT on psychogenic jerks.

Allopurinol TreatmenT And oxypurinol Concentrations in gouty patients: Knowing the therapeutic window.

- Demonstrating an association between oxypurinol concentration and the chance of succesfull lowering of urate concentration in gouty patients (defined as reaching urate concentrations < 0,30 mmol/l)

The Anti-Interleukin-1 in Diabetes Action trial

The aim of the Anti-Interleukin-1 in Diabetes Action trial (AIDA) study is to test the feasibility, safety/tolerability and potential efficacy of anti-IL-1 therapy in maintaining or enhancing beta-cell function in people with new-onset Type 1…

The influence of oral contraceptives on lamotrigine clearance in patients on lamotrigine in combination with valproic acid, carbamazepine or oxcarbazepine as compared to patients on lamotrigine only.

In a previous prospective study(4), we investigated in detail the effect of OCs on LTG clearance. However, LTG is frequently used in combination therapy. This raises the question as to what extent and how co-medication with other anti-epileptic…

Bilateral Cochlear Implantation Benefits in Adult Users of the HiRes 90K Bionic Ear System

1) Compare a group of bilateral users to a unilateral control group (between-subject design)2) Compare unilateral use to bilateral use after sequential implantation (within-subject design)3) Compare simultaneous bilateral implantation to sequential…