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PreCARA: Preconception Counselling in Active Rheumatoid Artritis and other chronic inflammatory arthritides;
Preconception counselling for women with rheumatoid arthritis (RA) or another chronic inflammatory arthritis and a pregnancy wish, which is evaluated in a prospective observational study monitoring pregnancy, delivery, postpartum period of the mother, and (growth) parameters of the child.

In the present study we will evaluate the standardized care protocol developed in our outpatient clinic, intended to guide counselling for medication use prior to pregnancy. This protocol guides treatment decisions based on disease activity,…

The influence of oral contraception on the 1 mg overnight dexamethasone suppression test

1. Examen if the outcome of the 1 mg Overnight Dexamethasone suppression test is influenced by the use of oral contraception.2. Examen how many weeks after ceasing the use of orale contraception the 1 mg Overnight Dexamethason suppression test is…

Intracranial pressure variability in migraine;
A prospective study to evaluate changes in intracranial pressure during different migraine attack phases

ObjectivesOur main hypothesis is that ICP shows a dynamic profile over the course of different attack phases in migraine. Therefore, we aim to detect dynamic changes in ICP in relation to different phases of the migraine attack. In concreto, the…

European Non-invasive Trisomy Evaluation (EU-NITE Study): Evaluation of a targeted analysis of cell free fetal DNA in maternal blood for prenatal diagnosis of fetal trisomies.

our primary aim is to validate a targeted analysis of circulating DNA in maternal blood by assessing the diagnostic accuracy for fetal trisomy 21. In addition, test characteristics for fetal trisomy 18 detection will be evaluated.

Toward a More Effective Treatment of Obesity: A RCT on Emotional Eating Reduction by Dialectical Behaviour Therapy

This study assesses the effectiveness of DBT in comparison to the effectiveness of the treatment as usual, the (standard) cognitive behavioural therapy, by using a randomised controlled design situated in the eating disorder and obesity unit of…

Serum allergens and innate lymphoid cells in eosinophilic esophagitis.

Primary: to analyze serum samples of adult EoE patients for IgE reactivity to recombinant allergens of common foods.Secondary: to demonstrate the presence of ILC2 in periferal blood of adult patients with eosinophilic esophagitis Tertiary: To store…

Is apathy associated with poor effort during neuropsychological assessment in patients with Alzheimer*s disease or Parkinson*s disease?

The general aim of this study is to explore how a motivational deficiency (i.e. apathy) related to neurodegenerative diseases is associated with effort and how it can be distinguished from intentional underperformance. We will investigate whether…

Effectiveness of including homocysteine screening in
cardiovascular risk management for older people: a pilot study

The objective of this study is to determine the feasibility of a RCT that study the effectiveness on mortality and morbidity of cardiovascular preventive medication in people >=75 years without previous cardiovascular disease, without…

*A prospective randomized multicenter study to demonstrate the superiority of the Barricaid® to discectomy for primary lumbar disc herniation*: Extended Follow-Up of the Barricaid® Annular Closure Device (ACD) Randomized Control Trial (RCT) Postmarket Cohort for Lumbar Disc Herniation and Interaction with Other Risk Factors

The purpose of this post-approval protocol amendment is to extend the follow-up of subjects who were originally enrolled in theRCT, EUBARD-CP_001 protocol. This study extension will examine the long-term survivorship of the Barricaid® ACD when…