26 results
The primary objective of this study is to analyse the microenvironment of the tumour, (sentinel) lymph nodes (i.e. various T-cell populations, antigen presenting cells and myeloid-derived suppressor cells) in patients with vulvar carcinoma. The…
The primary objective of this study is to analyse the microenvironment of the primary tumour and sentinel and non-sentinel lymph node(s) (i.e. various T-cell populations, antigen presenting cells and myeloid-derived suppressor cells) in patients…
To prospectively study the effect of salt restriction on the rise in blood pressure in response to anti-cancer treatment with the VEGF inhibitor sunitinib and regorafenib.
To gain insight into the biological pathways that are influenced by the CEEx30/31 mutations.
To compare, the perifoveal microvascular changes (non-perfusion areas) in the deep capillary plexus layer between Behçet patients with and without ocular involvement and control subjects, using OCT-A.
The objective of this pilot study is to assess the feasibility of CMR imaging, and to evaluate the accuracy of left ventricular (LV) functional and volumetric measurements in patients implanted with a CMR compatible CRT-D, with and without…
To examine the effect of a physical activity intervention on executive functioning, mental health and academic achievement in healthy adolescents. The secundaire objective is to examine the effect of a physical activity intervention on physical…
Objective: In this project we, as a collaborative network of Netherlands academic hospitals from Utrecht, Amsterdam, Rotterdam, Leiden and Groningen, propose to further optimize and validate MG-NIPD at early stages (week 8-10) of pregnancy, in order…
The goal is to gain more clarity in the wishes of the patient and family members by means of Advance Care Planning with the help of an early outpatiënt consultation of the PACT. This is hoped to show the intervention leads to a reduced number of…
We hypothesize that the cytokines secreted by HNSCC may perturb the hematopoiesis in patients. We wonder whether this perturbation can be restored after local treatment of the tumor.Primary objective: In this pilot study, we aim to prospectively…
* To determine the relationship between phenotypic and genetic characteristics of GBA-PD patients. Phenotypic characteristics will be obtained by patient dossier review. Genetic characteristics comprise of the GBA1 gene and a panel of SNPs,…
Primary Objectives* To estimate the effect size, at 4 and 8 weeks, of change from baseline in high- resolution computed tomography (HRCT)-based measurements of lobar volumes at functional residual capacity (FRC) and total lung capacity (TLC) in…
The primary study objective is to assess protein intake at the end of the first treatment cycle in patients with CRC or NSCLC undergoing first line treatment with chemo-, concurrent chemoradio- or immunotherapy who are receiving two servings of test…
This research project is divided into two projects. The first part of the study (Study 1) aims to find an answer to the question whether and to what extent biofeedback is a user-friendly and feasible intervention. In the main study (Study 2), we…
Case series study (10 persons with epilepsy-related anxiety symptoms and/ or posttraumatic stress):-To examine the potential effects of EMDR therapy in terms of reducing anxiety, from pre-treatment to post-treatment. Randomized controlled trial (75…
1. The primary objective of the European NAFLD Registry observational study is to assemble a cohort of well-characterised patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and to collect associated clinical information, biological samples and…
The current study will investigate the beneficial effects of an experimental congruent movement training (eye and hand movements), compared to a control intervention with only eye movements (visual scanning therapy). Primary objectives are changes…
The primary objective of this study is to optimize a workflow for identification of circulating melanoma cells in LA using flow cytometry. Secondary objectives include the detection of known mutations in different CMC subsets.
To determine the added value of e-consultation compared to a visit to the well baby clinic.
In this study we will examine the effectiveness and time course of the addition of a forensic network coach to treatment as usual in improving mental well-being among a forensic psychiatric outpatient population. Patients will be randomly allocated…