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Reducing symptoms of depression and anxiety in adolescents with inflammatory bowel disease in order to improve quality of life and the clinical course of disease

The primary objective is to determine the efficacy of a disease specific cognitive behavioral therapy program in adolescents with IBD and increased symptoms of depression or anxiety on reducing symptoms of depression. Secondary objectives are to…

The use of Fibrin sealant In total knee Replacement Surgery Trial. A prospective randomised multicentre study.

Is the application of CryoSeal (CS) in primary total knee replacement surgery beneficial for the patient with respect to a faster track and improved postoperative rehabilitation. The beneficial effect may be due to quicker functional knee…

Explaining plasticity after stroke

EXPLICIT aims tot obtain better functional outcome by early intensive rehabilitation. Next to clinical tests to measure improvement in function, neuroplasticity is assessed by fMRI, TMS and haptic robots. The combination of clinical outcome measures…

Comparison of celite activated clotting time with kaolin activated clotting time during cardiac surgery.

We want to compare duplicate measurements of celite ACT and kaolin ACT in patients undergoing cardiac surgery. In addition we want to measure heparin use during surgery in patients monitored with celite ACT and with kaolin ACT.In addition,…

Disrupting the rythm of depression: effectiveness and cost-effectiveness and mediating factors of preventive cognitive therapy, with or without antidepressants and compared to antidepressants alone, in the prevention of recurrent major depressive disorder.

The objective of this study is threefold:1) compare the effectiveness and cost-effectiveness of brief CT added to maintenance AD versus maintenance AD alone versus guided tapering or discontinuation of AD with brief CT.2) examine whether the…

HARP II-trial: Right-sided hand-assisted retroperitoneoscopic live donor nephrectomy versus standard laparoscopic living donor nephrectomy.

To determine the best approach for right-sided live donor nephrectomy i.e. to optimise donor*s safety and comfort .

Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Comparing REMICADE® (infliximab) and Placebo in the Prevention of Recurrence in Crohn*s Disease Patients Undergoing Surgical Resection Who Are at an Increased Risk of Recurrence

Primary ObjectiveThe primary objective of this study will be to compare the efficacy of infliximab with that of placebo in the prevention of clinical recurrence of CD through Week 76, defined as a composite endpoint that requires endoscopic…

Double-blind, placebo-controlled, multiple ascending-dose study to investigate the safety and tolerability of AZ01 in healthy volunteers.

Primary:- assess safety and tolerability and determine the maximum tolerated dose (MTD) of repeated doses or a single dose of AZ01 given as a subcutaneous (SC) or intravenous (IV) dose in healthy subjects. Dosing will not exceed the maximum feasible…

ARA 290 and the ventilatory response to hypoxia and pain responses in healthy volunteers

(1) To assess the effect of ARA 290 on the ventilatory response to hypoxia (and compare the effects to Epo); (2) To assess the effect of ARA 290 on the gradient over the tricuspid valve during hypoxia (and compare the effects to Epo); (3) To assess…

Sking hardening in polymorphic light eruption. Comparison of therapeutic effect of UVB hardening in the hospital with treatment at home with Sunshower

In this study we will evaluate the effect of Sunshower Medical device at home and compare it with the effect of customary UV hardening performed in the hospital to assess whether the former is not inferior to the latter treatment. The ultimate goal…

Functional MRI of food temptations: Effects of temptation exposure on the activation of reward and conflict areas in the brain.

Our main objective is to compare the effects of weak and strong food temptations on the activation of reward and conflict areas in the brain.

A pilot randomized controlled trial comparing the effect of a percutaneous and lipofilling technique in patients with a secondary Dupuytren*s contracture with standard fasciectomy surgery on convalenscence, contracture correction and recurrence rate.

To compare treatment of secondary Dupuytren*s contracture by standard limited (dermo)fasciectomy and by the modified percutaneous release combined with fat grafting. We focus specifically on return to function and if applicable to return to work (…

Influence of hyperglycaemia and sustained hypoxia on the hypoxic ventilatory response and the hypoxic pulmonary vasoconstriction.

In this study we want to investigate the effects of sustained hyperglycaemia and hypoxia on the hypoxic pulmonary vasoconstriction and hypoxic ventilatory response

A Clinical Safety and Efficacy Comparison of NEVANAC® 0.1% to Vehicle
Following Cataract Surgery in Diabetic Retinopathy Patients

Demonstrate superiority of NEVANAC® (nepafenac ophthalmic suspension) 0.1% relative to nepafenac vehicle based on the percentage of diabetic retinopathy patients who develop macular edema (defined as >=30% increase from pre-operative baseline…

Bard® PolySoft* pre peritoneal mesh versus Parietene* ProGrip* self-fixing semi-resorbable mesh and chronic inguinal pain development.

Objective of the Trial:Does the use of a Bard® Polysoft* preperitoneal mesh result in less chronic pain than after the use of a ProGrip*self-fixing semi-resorbable mesh for patients with an inguinal hernia repair through an anterior approach?

Towards a shortened sick leave duration of employees sick-listed due to common mental disorders

The objective of this study is to investigate:•Why do Dutch occupational physicians currently adhere only minimally to the guideline, and how can these barriers overcome? (phase 1)•Does adherence to this guideline lead to a shortened sick leave…

Volumetric Wear Measurements in Total Knee Arthroplasty; Cross-linked versus Standard Polyethylene insert

The objective of this research is to investigate in vivo by means of RSA the amount of wear of the insert very secure.Through frequently taken RSA measurements over a 3 year period, we might be able to predict the longevity of the XLPE insert.

Viscosity of PMMA Bone Cement in Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fractures: A Randomized Controlled Trial

Establishment whether usage of high viscosity PMMA bone cement in PVP for OVCFs leads to a reduction in leakage incidence compared to usage of conventional (low-medium) viscosity PMMA bone cement in PVP for OVCFs.Since evidence is scarce or…

A randomised multicenter study comparing anterior cervical discectomy with or without interbody fusion and arthroplasty in the treatment of cervical disc herniation.

To show whether Active C disc prosthesis is more effective than anterior discectomy with or without interbody fusion 1 year after surgery. Moreover, the incidence of adjacent disc degeneration will be evaluated 5 years after surgery.

Oxytocin and social information processing

In this study we will try to replicate and extend the findings of Domes et al (2007) of oxytocin effects on *mind-reading* in two specific groups of participants; i.e. in a group of high-functioning individuals with autism, and a normal comparison…