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Disrupting the rythm of depression: effectiveness and cost-effectiveness and mediating factors of preventive cognitive therapy, with or without antidepressants and compared to antidepressants alone, in the prevention of recurrent major depressive disorder.

The objective of this study is threefold:1) compare the effectiveness and cost-effectiveness of brief CT added to maintenance AD versus maintenance AD alone versus guided tapering or discontinuation of AD with brief CT.2) examine whether the…

Viscosity of PMMA Bone Cement in Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fractures: A Randomized Controlled Trial

Establishment whether usage of high viscosity PMMA bone cement in PVP for OVCFs leads to a reduction in leakage incidence compared to usage of conventional (low-medium) viscosity PMMA bone cement in PVP for OVCFs.Since evidence is scarce or…

Single- vs. double-balloon enteroscopy in small bowel diagnostics: A randomized controlled single-blind multicenter trial

The primary aim of the present study is to compare the new SBE system with the standard DBE system with respect to completeness of visualisation and insertion depth of the small bowel, as well as complications during the procedure.

Innovation of diagnostics and treatment of selective mutism: towards personalized care

The objective of this study is to1) validate a specific Selective Mutism Questionnaire (SMQ) to screen adequately for selective mutism; 2) test the effectiveness of an innovative treatment protocol for selective mutism.

MOODSTRATIFICATION IMMUNOSTRATA Groningen
Premature immune ageing and spinning therapy in mood disorders

Primary objective:To assess whether the state of premature immune ageing (senescent CD8+ T cells) modify treatment response to physical endurance intervention therapy in depressed patients. We will compare the mood-beneficial effects of physical…