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A phase I/II, open-label, dose-escalating study to evaluate the safety, tolerability and pharmacokinetics of twice daily oral midostaurin and to evaluate the preliminary clinical and pharmacodynamic response in pediatric patients with relapsed or refractory leukemia

This is a phase I/II pediatric dose-ranging study that will evaluate the safety, tolerability and pharmacokinetics of midostaurin in children <18 years of age and >= 3 months who have relapsed or refractory leukemias that may benefit…

Research into the efficacy and cost-effectiveness of short term, cost free and anonymous sex counselling to improve (mental) health (including development of protocol and training plan)

This project has three objectives:1. DevelopmentThe development objective is to prepare the implementation of this preventive intervention on the onehand by developing and accommodating protocols for sex counselling in the important fields of…

Pectoralis Major Tendon Transfer for Winging Scapula

Objective is to monitor muscle function before and after a solitary transfer of the pectoralis major for patients suffering a winged scapula. Clinical results, assessed in terms of pain experience, maximal Range of Motion, arm force and arm function…