21 results
To analyse long-term structural joint changes after knee joint distraction as a treatment for knee osteoarthritis by use of radiographs
Relevancy: Groin explorations are regularly performed procedures in vascular surgery. To date, the chosen technique will be either electrocoagulation or the Ligasure, depending on the operator*s preference. It is yet unclear whether the chosen…
The main objective of our research is to study the effectiveness of the SAFER pregnancy intervention in reducing risk behaviour (i.e. smoking and alcohol use) in pregnant women and women with the wish to conceive. The secondary objectives focus on…
To evaluate the cost-effectiveness of treatment with a circumferential cast compared to treatment with a splint, in patients with a reduced distal radius fracture. The hypothesis is that reduced distal radius fractures treated with a circumferential…
To characterise and compare neurobiological mechanisms underlying behavioural effects of three different rTMS treatment protocols in OCD using multimodal neuroimaging, with a focus on neuroplasticity.
Primary Objectives: - Is IBA non-inferior to CBT in treating patients with OCD?Secondary Objectives:-* Does treatment modality predict pre- to posttreatment changes in neural networks, and is this related to symptom reduction and changes in…
To explore feasibility of intraluminal oxygen administration at the site of the anastomosis in patients who underwent an esophagectomy.
To personalize MTX treatment in CD through a) therapeutic drug monitoring (TDM) of MTX and b) prediction of MTX efficacy. We will develop TDM by measuring MTX concentrations [MTX-polyglutamate concentration in erythrocytes] and determining their…
The primary goal is of this pilot study is to investigate the effects of Computerised Interactive Remediation of Cognition - a Training for Schizophrenia (CIRCuiTS), on the cognitive functioning of the described group of service users. It is…
To investigate whether the PK-PD target of ceftazidime (50%T>MIC) is attained in the first 24 hours of treatment in adult patients on general wards with adequate and impaired renal function receiving regular and reduced doses of ceftazidime.
To set up a cohort that will serve as a multi-trial platform and facilitate evaluation of new interventional treatment for prostate cancer.
In this study, we will test whether STN-DBS related apathy can be reversed by switching stimulation to a more dorsal contact on the electrode.
Does blockade of the CD40-CD40L pathway reduce T and B cell mediated alloreactivity after kidney transplantation?
The aim of this study is to investigate 1. the extent to which patients who have paresis/non-spastic paralysis of the lower extremity and who are moderately active experience an improvement in the (trunk) balance through the use of a computer-…
The main objective is to compare the effectiveness of two sessions PNE versus care as usual on pain levels 3 months after surgery in patients undergoing TKA. Secondary objective(s) is to explore the effectiveness of two sessions PNE in comparison to…
The present pilot study will examine whether chronic stress is related to response to immunotherapy with checkpoint inhibitors for metastasized melanoma. Stress will be assesed by Hair cortisol, Salivary cortisol and some validated questionnaires (…
1) To collect information on patient characteristics, short- and long-term clinical and patient-reported outcomes; and 2) to create an infrastructure for efficient, fast, and pragmatic randomized evaluation of new interventions.
Overall aim: To evaluate the relationship between airway structure and function in patients with chronic bronchitis treated with metered cryospray (MCS).1) To identify the molecular and cellular targets of MCS treatment and determine the mechanistic…
Our primary goal is to develop an easy access cognitive training for older patients with mood disorders suffering from (subjective) cognitive complaints. We want to study the effect on both objective and subjective functioning. Secondary, we aim to…
To investigate the efficacy and the mechanisms of action of an anti-reflux mucosectomy in patients with gastroesophageal reflux disease.