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The state of the (sentinel) lymph node and tumour microenvironment in patients with HPV-positive and HPV-negative cancer of the vulva.

The primary objective of this study is to analyse the microenvironment of the tumour, (sentinel) lymph nodes (i.e. various T-cell populations, antigen presenting cells and myeloid-derived suppressor cells) in patients with vulvar carcinoma. The…

The state of the (sentinel) lymph node and tumour microenvironment in patients with cancer of the cervix.

The primary objective of this study is to analyse the microenvironment of the primary tumour and sentinel and non-sentinel lymph node(s) (i.e. various T-cell populations, antigen presenting cells and myeloid-derived suppressor cells) in patients…

Observational Assessment of Clinical and Genetic Risk Factors Associated with GBA1-Associated Parkinson's Disease Clinical Progression: A genetic Analysis and Retrospective Study

* To determine the relationship between phenotypic and genetic characteristics of GBA-PD patients. Phenotypic characteristics will be obtained by patient dossier review. Genetic characteristics comprise of the GBA1 gene and a panel of SNPs,…

Protein intake in patients with colorectal or lung cancer during first line treatment with chemo(radio)- or immunotherapy when receiving a low volume, energy dense and high protein oral nutritional supplement: a randomized, controlled study

The primary study objective is to assess protein intake at the end of the first treatment cycle in patients with CRC or NSCLC undergoing first line treatment with chemo-, concurrent chemoradio- or immunotherapy who are receiving two servings of test…

An exploratory study to biotype adult patients with unipolar depression using digital technologies

Primary Objectives* To characterize patients with unipolar depression in terms of social, physical, biometric activity, and neurophysiological and -psychological data outcomes using digital technologies * Evaluating the feasibility and subjective…