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An open-label study to determine the usefulness of the dried blood spot method for phenotyping and genotyping of CYP450 enzymes and the determination of trace elements in healthy volunteers.

The objective of this research is to compare the results of the analysis of midazolam between the dried blood spot method, plasma and whole blood.

Quantification of muscular fatty degeneration in brachial plexus injury patients

The purpose of this study is: 1) to develop a method to quantify muscular fat content in brachial plexus injury patients;2) to investigate whether muscular fat content is more in the affected arm compared to the contralateral arm in BPI patients;3)…

Muscle activation patterns of the supraspinatus and deltoid muscle in abduction of the arm:
- Motion generator or GH (de)stabilizator? -

- To investigate whether increased arm moment loading (with a constant exerted abduction force) in healthy controls leads to a relatively larger increase in deltoid muscle activation as compared to increase in supraspinatus muscle activation.- To…

A pilot randomized controlled trial comparing the effect of a percutaneous and lipofilling technique in patients with a secondary Dupuytren*s contracture with standard fasciectomy surgery on convalenscence, contracture correction and recurrence rate.

To compare treatment of secondary Dupuytren*s contracture by standard limited (dermo)fasciectomy and by the modified percutaneous release combined with fat grafting. We focus specifically on return to function and if applicable to return to work (…

Assessment of Capnography in Monitoring Patients during Deep Sedation with Propofol

At the Centre for Contraception, Sexuality and Abortion Leiden, abortion procedures are performed under deep sedation using Propofol. Patient*s monitoring is performed by nurses qualified in patient sedation management, using pulse oximetry and…

TRanslabial 3D-Ultrasonography for DIagnosing Levator defects

Objective:Primary aim of the study is estimating the diagnostic accuracy of translabial 3D ultrasonography of thepelvic floor as compared to MR imaging, the reference standard, for diagnosing levator defects inwomen with POP. Our secondary aim is…

Digital rectal examination and transabdominal ultrasound as diagnostic tools for constipation. Examination of the rectum in children with urology symptoms

Primary: To investigate if there is a correlation between findings of transabdominal ultrasound measurement of the rectum and rectal digital examination. Secondary: To investigate if there is a correlation between an enlarged rectum (diameter &…

Bard® PolySoft* pre peritoneal mesh versus Parietene* ProGrip* self-fixing semi-resorbable mesh and chronic inguinal pain development.

Objective of the Trial:Does the use of a Bard® Polysoft* preperitoneal mesh result in less chronic pain than after the use of a ProGrip*self-fixing semi-resorbable mesh for patients with an inguinal hernia repair through an anterior approach?

Optical vulvar biopsy by optical coherence tomography (OCT)

To determine the diagnostic value of OCT in patients with (suspicion of) vulvar intraepithelial neoplasia and in patients with vulvar cancer.

In vivo and in vitro sensitivity measurements of the circadian system. Investigating individual differences.

To gain insight into individual differences in sensitivity of the circadian system. In vivo measured by the sensitivity of melatonin suppression, thermoregulatory processes and psychological functioning to full spectrum and blue reduced light, and…

Correlation between salivary testosterone and free testosterone

To study the correlation between salivary T and (measured and calculated) serum free T.

Viscosity of PMMA Bone Cement in Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fractures: A Randomized Controlled Trial

Establishment whether usage of high viscosity PMMA bone cement in PVP for OVCFs leads to a reduction in leakage incidence compared to usage of conventional (low-medium) viscosity PMMA bone cement in PVP for OVCFs.Since evidence is scarce or…

Treatment of severe obstructive sleep apnea syndrome: evaluation of a therapy combining continuous positive airway pressure with an oral appliance: a pilot study

The purpose of this pilot study is to evaluate the feasibility, efficacy, safety of and patients* compliance to an OA-CPAP for planning a main randomised controlled study. The main objective is to investigate if a patient is treated effective,…

A pilot study evaluating response to induction chemotherapy with oxaliplatin, capecitabine and bevacizumab in patients with extensive peritoneal carcinomatosis of colorectal origin.

* The primary objective of this study is:- the study of the response rate and the macroscopic and microscopic response charactheristics of neo-adjuvant chemotherapy of patients with peritoneal carcinomatosis (PC) of colorectal origin. * Secundary…

Modeling the respiratory effects of subanesthetic doses of propofol under closed-loop or non-steady-state conditions without and with a remifentanil background infusion in healthy volunteers.

Study aims (see page 2 of the protocol)a. To assess the dose-response relationship of propofol on breathing.b. To assess the interaction of propofol and remifentanil on breathing.c. To qunatify the data under closed-loop conditions using an emprical…

Investigation of gene variants associated with resistance and susceptibility to HIV-1 infection in HIV-1 exposed but uninfected individuals with haemophilia A.

To identify human genetic variants that influence susceptibility or resistance to HIV infection

Relationship between exhaled markers and airway pathology in smokers with and without airflow obstruction

The aim of this study is to evaluate whether there is a correlation between the sbN2-test, markers in exhaled air and the inflammatory cells in the small airways.

A prospective trial of the use of CT colonography to screen for colonic neoplasia in patients prior to liver transplantation.

This study aims to show that CT colonography is feasible in combination with 4-phase CT of the liver in one session, has good diagnostic accuracy and is associated with fewer complications and is therefore the investigation of choice in these…

Cardiac sympathetic innervation imaging in patients with trastuzumab induced cardiotoxicity

We intend to study the effect of trastuzumab on the cardiac neuronal activity in patients with HER-2 positive breast cancer by using iodine-123 meta-iodobenzylguanidine (123I-MIBG) and cardiac imaging. 123I-MIBG, an analogue of the false…

Sensitive Imaging in Ankylosing Spondylitis

* To study the relationship between inflammation on MRI and syndesmophyte formation with very detailedimaging methods: radiography, computed tomography (CT), 3 and 7 Tesla MRI. * To examine the time order of pathologic changes like inflammation,…