24 results
(1) To determine frequency of antibody-mediated encephalopathy in adults with new-onset epilepsy/status epilepticus or chronic epilepsy. (2) To assess outcome of antibody-mediated encephalopathy in adults with epilepsy, and identify markers for good…
The overall aim of the study is to improve diagnostic and therapeutic options for people with CF, especially in the context of young children and novel CFTR-targeting drugs. Primary Objective: 1. to demonstrate relations between CFTR genotype,…
The primary objective of this study is to determine the Optical Density Ratio (ODR) for the prototype CORIMAP camera and compare the ODR values with the Oxymap T1 mounted on a regular fundus camera in a healthy adult population. For comparison, it…
To evaluate whether blood CC12gene expression defines disease status (Stage I-IV, stable or progressive) and whether the blood CC12gene expression predicts response to therapeutic intervention.
The main objective of the panel study is to evaluate the associations between short-term variation of concentrations of key air pollutants (NO2, PM2.5, PM10, and ultrafine particles), measured on a fine spatial and temporal resolution, and short-…
The primary objective is to determine the efficacy of a disease specific cognitive behavioral therapy program in adolescents with IBD and increased symptoms of depression or anxiety on reducing symptoms of depression. Secondary objectives are to…
This study aims to gain more insight in the sexual development of adolescent boys with ASDs.The main research question is: How do high functioning boys with ASD develop sexually? The main research question is worked out in 2 parts/1. Which sexual…
In this research project it is investigated if abdominal ultrasound measurement of prostate volume performed by the GP is equivalent to the prostate volume measured by the transrectal ultrasound (TRUS) performed by the urologist. Also the effect on…
To explore the role of 4D PET-CT in radiation treatment planning, relative to standard 3D PET-CT.
The purpose of this study is to contribute to the knowledge of feeding problems in infants with CL, CP and CLP. Our evidence based results can help clinicians, involved in the care of cleft patients, in providing proper information and professional…
To determine the effect of a single red blood cell transfusion on the microcirculation.
The current study aims to further our understanding of the relationship between baseline measures - such as impulsivity, working memory and social support - and the effects of enhancing dopamine (via methylphenidate administration) across a wide…
Identify the effect of tDCS parameters on motor learning in healthy individuals by measuring effects on visuomotor adaptation rate and retention, and study the influence of a common BDNF mutation.
To evaluate the cost-effectiveness of arthroscopic partial meniscectomy compared to non-operative treatment strategy. The hypothesis is that an arthroscopic partial meniscectomy is a cost-effective intervention to treat patients with clinical…
The objective of this study is to investigate the use of retinal oximetry in children, between five and seventeen years of age, with (vitreo-) retinopathies and oxygen-related diseases of the retina by means of an Oxymap T1 fundus camera.
The aim of this study is to develop and validate the ELISA and potential other assays (e.g. LC-MS), in order to measure drug concentration levels. For this, blood and other material will be collected.
to combine and validate diagnostic tests for the prediction of clinical response to therapy with biologics in patients withreumatoid artritis.
Primary objective: Part A: MR cardiopulmonary exercise protocol validation: To validate the protocol of the CMR-ergometer against conventional ergometers in young healthy adultsPart B: CMR exercise study To examine cardiorespiratory structure and…
The primary objective of the study is to determine the effect of food on the uracil and dihydrouracil levels in plasma.Secondary objectives are:* To investigate inter- and intra-individual variations in uracil and dihydrouracil levels in plasma* To…
To describe the pharmacokinetic (PK) profile and effectiveness of sarilumab in patients with pcJIA in order to identifythe dose and regimen for continued development in this population.