43 results
The overall aim of the study is to improve diagnostic and therapeutic options for people with CF, especially in the context of young children and novel CFTR-targeting drugs. Primary Objective: 1. to demonstrate relations between CFTR genotype,…
The primary objective of this study is to determine the Optical Density Ratio (ODR) for the prototype CORIMAP camera and compare the ODR values with the Oxymap T1 mounted on a regular fundus camera in a healthy adult population. For comparison, it…
The primary objective of this study is to analyse the microenvironment of the tumour, (sentinel) lymph nodes (i.e. various T-cell populations, antigen presenting cells and myeloid-derived suppressor cells) in patients with vulvar carcinoma. The…
To evaluate whether blood CC12gene expression defines disease status (Stage I-IV, stable or progressive) and whether the blood CC12gene expression predicts response to therapeutic intervention.
The main objective of the panel study is to evaluate the associations between short-term variation of concentrations of key air pollutants (NO2, PM2.5, PM10, and ultrafine particles), measured on a fine spatial and temporal resolution, and short-…
The primary objective of this study is to analyse the microenvironment of the primary tumour and sentinel and non-sentinel lymph node(s) (i.e. various T-cell populations, antigen presenting cells and myeloid-derived suppressor cells) in patients…
To prospectively study the effect of salt restriction on the rise in blood pressure in response to anti-cancer treatment with the VEGF inhibitor sunitinib and regorafenib.
To gain insight into the biological pathways that are influenced by the CEEx30/31 mutations.
To compare, the perifoveal microvascular changes (non-perfusion areas) in the deep capillary plexus layer between Behçet patients with and without ocular involvement and control subjects, using OCT-A.
The aim of this study is to develop and validate the ELISA and potential other assays (e.g. LC-MS), in order to measure drug concentration levels. For this, blood and other material will be collected.
to combine and validate diagnostic tests for the prediction of clinical response to therapy with biologics in patients withreumatoid artritis.
The objective of this pilot study is to assess the feasibility of CMR imaging, and to evaluate the accuracy of left ventricular (LV) functional and volumetric measurements in patients implanted with a CMR compatible CRT-D, with and without…
Primary objective: Part A: MR cardiopulmonary exercise protocol validation: To validate the protocol of the CMR-ergometer against conventional ergometers in young healthy adultsPart B: CMR exercise study To examine cardiorespiratory structure and…
Primary objective: To accurately assess the direct functional consequences of high versus low phenylalanine levels in adult patients with PKU, using eye-hand coordination testing in tasks of different cognitive complexity. Secondary objective: To…
To examine the effect of a physical activity intervention on executive functioning, mental health and academic achievement in healthy adolescents. The secundaire objective is to examine the effect of a physical activity intervention on physical…
Objective: In this project we, as a collaborative network of Netherlands academic hospitals from Utrecht, Amsterdam, Rotterdam, Leiden and Groningen, propose to further optimize and validate MG-NIPD at early stages (week 8-10) of pregnancy, in order…
The goal is to gain more clarity in the wishes of the patient and family members by means of Advance Care Planning with the help of an early outpatiënt consultation of the PACT. This is hoped to show the intervention leads to a reduced number of…
The primary objective of the study is to determine the effect of food on the uracil and dihydrouracil levels in plasma.Secondary objectives are:* To investigate inter- and intra-individual variations in uracil and dihydrouracil levels in plasma* To…
The primary objective of this project is to map differences in joint loading between athletes receiving visual feedback and those who will not receive visual feedback in both retention and transfer to field-specific situations. From there. we will…
We hypothesize that the cytokines secreted by HNSCC may perturb the hematopoiesis in patients. We wonder whether this perturbation can be restored after local treatment of the tumor.Primary objective: In this pilot study, we aim to prospectively…