703 results
To investigate the feasibility and safety of preoperative stereotactic radiotherapy of 4cm pancreas in patients undergoing pancreatoduodenectomy at high risk of developing postoperative pancreatic fistula (>25%).
To confirm the safety and performance of the TriClip* Tricuspid Valve Repair System in a real-world setting.
The objective of this randomized noninferiority trial is to determine whether INTELLiVENT*ASV with sidestream capnography is noninferior to INTELLiVENT*ASV with mainstream capnography with regard to the percentage of breaths in a broadly accepted…
The aim of this adaptive multicentre randomized controlled trial is to maintain patients at a target blood pressure level with a sufficient margin from the minimal acceptable blood pressure threshold of a MAP of 65 mmHg to reduce the incidence of…
The primary aim of this phase II trial is to assess whether a progressive resistance training program can slow down neurodegeneration in people with PMS. Additional objectives of this study are: 1. To determine the effect of exercise on disability.…
The main objective of this study is:This study investigates whether diagnosis and treatment of challenging behaviour, as provided by an specialist team of mental health care professionals and intellectual disability professionals, when optimising…
Our overall aim is to assess the seroprevalence of SARS-CoV-2 antibodies in an international population of pwCF and to examine associations between SARS-CoV-2 infection and clinical risk factors for infection, as well as subsequent clinical outcomes…
To characterize glioma and epileptogenic tissue with 7T metabolic MRI, and validate their metabolic imaging characteristics with histopathological measures.
Primary Objective: To evaluate the feasibility and acceptability of the culturally and contextually adapted WHO*s PM+ intervention for Arabic, Tigrinya and Ukrainian speaking refugee youth living in the Netherlands.Secondary Objective:1. To evaluate…
Primary Objectives• Characterize day-to-day, within-day, intra-individual and inter-individual variability of GCase activity in healthy participants and patients with Parkinson*s disease with a GBA1 mutation.Secondary Objectives• Assess variability…
Our primary goal is to develop an easy access cognitive training for older patients with mood disorders suffering from (subjective) cognitive complaints. We want to study the effect on both objective and subjective functioning. Secondary, we aim to…
Over the last decades, much fundamental knowledge has been obtained about the neurobiology of antisocial behavior on group level. The main aim of the current study is to translate this group-level knowledge to individualized, developmental profiles…
The main goal is to achieve a means of communication solely based on brain signals for severely paralyzed patients. Success will constitute a significant advance in the field of BCI and of severe paralysis because it will be the first system that…
Therefore, the purpose of our study is to study, in peanut and nut allergic children:1. the relationship between gut permeability and threshold levels to peanut or nuts;2. the effect of an immune-supportive diet on gut permeability, coexisting…
To investigate the efficacy and the mechanisms of action of an anti-reflux mucosectomy in patients with gastroesophageal reflux disease.
Main objective: - To investigate pyruvate kinase thermal stability in haemoglobinopathies.Secondary objectives: - To investigate the possibility of stimulation of PK activity and thermal stability by use of allosteric activators- To investigate…
The objective of this study is to assess the efficacy and cost-effectiveness of a treatment strategy starting with surgical intervention compared to a starting treatment with steroid injection.
To document clinical efficacy of ArthroSave*s Knee-Reviver at 1, 2 and 5 years after distraction by:1st: an increase in WOMAC score (pre-treatment vs. follow-up).2nd: an increase in radiographic joint space width (pre-treatment vs. follow-up)
Primary Objective (Double Blind)To assess the efficacy of Kamada-AAT for Inhalation administered at a dose of 80 mg daily versus (vs) placebo, with efficacy measured by FEV1 post bronchodilator change from baseline at 104 weeks. OLE Objectives1. To…
The main objectives of this project are to increase our knowledge of factors playing a role in the maintenance of body image concerns in eating disorder patients. More specifically, we will examine the involvement of disgust-based avoidance of…