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Cognitive Decline in Older Patients with End stage Renal Disease

Knowledge on the magnitude of the decline and the pathophysiological mechanism can eventually help us topostulate an algorithm for well-balanced decision making in treatment strategies in the elderly CKD patients.This knowledge will be firmly…

Disruptions of the day-night rhythm after treatment for a non-functioning pituitary adenoma; a cross-sectional study using actigraphy.

1. Are there differences between patients and controls in circadian movement rhythmicity and sleep duration?2. Are these objective measures associated with subjective sleep complaints?3. Are these objective measures associated with decreased quality…

Mindfulness Based Cognitive Therapy (MBCT) for treatment refractory anxiety disorders

Objective: The primary aim of the present study is to investigate the effectiveness of MBCT in a group format versus TAU in a group format for treatment refractory anxiety disorders Furthermore; we will investigate mediators associated with…

Genetic immunological causes of recurrent miscarriages;
'HLA sharing as a cause of recurrent miscarriages'

Does HLA sharing in couples with recurrent miscarriage play a role in recurrent miscarriage of unknown etiology?

Behavioral and psychological characteristics of children with narcolepsy

With this study we aim to investigate the emotional development, behavior, social behavior, variation in personality traits and intellectual functioning in a group of children who are diagnosed with narcolepsy with of without cataplexie, according…

Assessment of blood flow velocity and oximetry using non-invasive retinal and cutaneous microcirculation imaging in sickle cell disease (SCD) patients and healthy volunteers.

Assessment of the cutaneous and retinal microcirculation in SCD patients and matched controls:- Long- and short-term repeatability of LSCI and NiRFI ;- Comparison of cutaneous and retinal microcirculation between SCD patients and matched healthy…

Neurocognitive Development of Reading Comprehension

The main objective of this proposal is to request permission for recruitment and participation of individuals between ages 8 and 30 in an fMRI session and several behavioral testing sessions. These studies are aimed at relating brain development to…

Excitability of the motor cortex during motor imagery and observation in patients with Complex Regional Pain Syndrome (CRPS) and tonic dystonia

to find evidence for frontal inhibition during planning of explicit movements just as seen in patients with conversion disorders.

Pituitary hormone secretion in patients with IGSF1 mutation

The objective of the current proposal is to further explore the pathophysiological changes that occur in patient with an IGSF1 mutation, using an established method for assessing hormone secretory characteristics.

A randomised, double-blind, parallel group, placebo-controlled multi-centre Phase III study to assess the efficacy and safety of olaparib versus placebo as adjuvant treatment in patients with germline BRCA1/2 mutations and high risk HER2 negative primary breast cancer who have completed definitive local treatment and neoadjuvant or adjuvant chemotherapy.

This study has been transitioned to CTIS with ID 2024-511096-15-00 check the CTIS register for the current data. To assess the safety and tolerability of adjuvant treatment with olaparib

Phase III study comparing R-CODOX-M/R-IVAC versus dose-adjusted EPOCH-R (DA-EPOCH-R) for patients with newly diagnosed high risk Burkitt lymphoma

Primary objective:- To confirm in a multicenter setting an improvement in EFS to 95% at 2 years of DA-EPOCH-R in patients with newly diagnosed high risk Burkitt lymphoma as compared to an expected EFS of 72% at 2 years for the control arm R-CODOX-M/…

The prospective data collection initiative on on small bowel, colorectal and anal cancer - a prospective observational cohort study.

The main objectives of this project are:- To start a prospective observational cohort study of patients who have been diagnosed with CRC, small bowel and anal cancer and follow them from time of diagnosis until death.- To prospectively collect data…

A Phase 3, Randomized, Open-Label Study of Nivolumab Combined with Ipilimumab Versus Sunitinib Monotherapy in Subjects with Previously Untreated, Advanced or Metastatic Renal Cell Carcinoma

This study has been transitioned to CTIS with ID 2023-504761-23-00 check the CTIS register for the current data. The co-primary endpoints of this study are PFS in intermediate and poor-risk subjects, as assessed by an Independent Radiology Review…

A prospective evaluation of pancreatic cyst surveillance, based on the consensus statement, formulated by the European study group on cystic tumours of the pancreas

First, to establish the yield of the currently propagated pancreatic cyst surveillance program, and second, to identify possible alternative surveillance strategies, which might be more (cost) effective.

Linking multimodal network imaging and cognitive functioning in glioma patients

The current study aims to primarily investigate associations between multimodal networks in glioma patients. Secondary objectives include investigation of the correlations between multimodal neural networks and cognition and epilepsy and linking…