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In frail patients with a hip fracture who are not eligible for surgery: a prospective multicenter cohort study

PENG block with phenol provides better pain relieve and mobility, and therefore quality of life, compared to current pain relieve strategies in patients with a hipfracture who are not eligible for surgery

Sentinel lymph node detection of cervical occult lymph node metastases in patients with parotid gland carcinoma by means of sentinel node biopsy using 68-galium-tilmanocept PET-CT.

This study has been transitioned to CTIS with ID 2024-514233-37-00 check the CTIS register for the current data. To evaluate the feasibility and prove the concept of sentinel node biopsy in patients with carcinoma of the parotid gland and scheduled…

Emotion perception and expression in patients with a functional neurological disorder

The primary objectives are to: (1) Examine whether emotional incongruence (i.e., the mismatch between self-reported emotion and observed emotion from facial expression) is more common in patients with FND than non-FND control groups (healthy…

A randomised double-blind placebo-controlled clinical trial investigating the effect and
safety of oral semaglutide in subjects with early Alzheimer*s disease (EVOKE plus)

This study has been transitioned to CTIS with ID 2023-506918-45-00 check the CTIS register for the current data. Primary objectiveTo confirm the superiority of oral semaglutide versus placebo on the change in cognition and function in subjects with…

A Phase 3, Multi-center, Open-label Extension Study to Assess the Safety and Efficacy of Viltolarsen in Ambulant Boys with Duchenne Muscular Dystrophy (DMD)

This study has been transitioned to CTIS with ID 2023-507146-91-00 check the CTIS register for the current data. Primary Objective:• To evaluate the safety and tolerability of viltolarsen administered intravenously (IV) at weekly doses of 80 mg/kg…

Endoscopic drainage of presumed resectable perihilar cholangiocarcinoma using a novel design short fully covered self-expanding metal stent with retrieval string (CHORDA)

To explore feasibility and efficacy of endoscopic unilateral drainage of patients with presumed perihilar cholangiocarcinoma eligible for major liver resection using a novel fully covered metal stent with a retrieval string.

DIAGNOSTIC ARTHROSCOPY VERSUS ARTHROCENTESIS AS INITIAL TREATMENT FOR ARTHRALGIA OF THE TEMPOROMANDIBULAR JOINT
A mono-center single-blind randomized controlled trial

To evaluate the effectiveness of diagnostic arthroscopy in reducing clinical symptoms compared to arthrocentesis under local anesthesia as initial treatment in patients with arthralgia (with or without reduced mobility) of the temporomandibular…

An open label, multi-center roll-over study to assess long-term safety in patients who are ongoing or have completed a prior global Novartis or GSK sponsored Tafinlar (dabrafenib) and/or Mekinist (trametinib) study and are judged by the investigator to benefit from continued treatment

This study has been transitioned to CTIS with ID 2023-509318-13-00 check the CTIS register for the current data. This is an open-label, multi-center, roll-over study designed to provide continued access to subjects who have previously participated…

A randomised double-blind placebo-controlled clinical trial investigating the effect and
safety of oral semaglutide in subjects with early Alzheimer*s disease (EVOKE)

This study has been transitioned to CTIS with ID 2023-506919-18-00 check the CTIS register for the current data. Primary objectiveTo confirm the superiority of oral semaglutide versus placebo on the change in cognition and function in subjects with…

The effects of an oncology tailored nutritional intervention on the bioavailability and immune-activity of PD-1 immune checkpoint inhibitors in patients with lung cancer:
*Nutritional intervention in cancer immunotherapy (NutriCim) *

The aim is to investigate whether it is feasible to perform a 12-weeks nutritional intervention study in NSCLC patients on PD-1 ICI, and to effectively assess their nutritional, immune, and microbial status, with the intention to use this…

Enhancing positive schemas with tdcs: a pilot study

We aim to investigate the relationship between positive schema activation and subsequent tests of emotional schema memory, and whether tDSC during positive schema activation can facilitate retrieval of emotional memory for positive information in…

Microvascular and Cardiovascular Status of Females with and without Migraine

The primary objective is to determine and compare the microvascular status between middle-aged women with and without migraine. Secondary objectives include a determination of the agreement and reproducibility of two devices which measure the blood…

Neo-adjuvant FOLFOXIRI and chemoradiotherapy for high risk (*ugly*) locally advanced rectal cancer.

This study has been transitioned to CTIS with ID 2023-509758-74-00 check the CTIS register for the current data. The aim of this study is to assess the effectiveness of the addition of neoadjuvant induction FOLFOXIRI systemic therapy to…

A phase Ib/II randomized double-blind placebo controlled trial evaluating the effect of Nivolumab for patients with in-transit melanoma metastases treated with isolated limb perfusion (NivoILP trial)

This study has been transitioned to CTIS with ID 2023-509265-21-00 check the CTIS register for the current data. To evaluate safety and the effect of isolated limb perfusion together with nivolumab as a way to increase efficacy and give further…

Phase Ib/II Trial of Pembrolizumab (MK-3475) Combination Therapies in Metastatic
Castration-Resistant Prostate Cancer (mCRPC) (KEYNOTE-365)

This study has been transitioned to CTIS with ID 2023-506987-15-00 check the CTIS register for the current data. 1) Objective: To evaluate the safety and tolerability of the pembrolizumab combination therapy.2) Objective: To estimate PSA response…

PSMAfore: A phase III, Open-label, Multi-Center, Randomized Study Comparing 177Lu-PSMA-617
vs. a Change of androgen receptor-directed therapy in the Treatment of Taxane Naïve Men with Progressive Metastatic Castrate Resistant Prostate Cancer

This study has been transitioned to CTIS with ID 2023-507772-50-00 check the CTIS register for the current data. The purpose of this study is to determine whether 177Lu-PSMA-617, given for 6 cycles at a dose of 7.4 Gigabecquerel (GBq) (200…

*Appraising CFX Treatment for Concussion*

This study will investigate the potential value of CFX treatment, by prospective monitoring of functioning in patients that undergo this treatment. Likewise, aspects of the treatment that are important for patient experience will be systematically…

Access to Pirfenidone Solution for Inhalation (AP01) for Treatment of Progressive, Fibrosing Interstitial Lung Diseases, including Idiopathic Pulmonary Fibrosis

This study has been transitioned to CTIS with ID 2024-515964-30-00 check the CTIS register for the current data. • Allow patients to continue or start AP01 therapy for the treatment of ILD and IPF prior to regulatory approval or until the study is…

In Balans: the (cost-)effectiveness of the In Balans fall prevention training on falls and fall injuries in community-dwelling older adults with an increased risk of falls

The aim of this study is to investigate the (cost-)effectiveness of the 'In Balans' fall prevention program. We will research the effect of 'In Balans' on the number of falls, fall injuries, physical performance (including…

Impact of a cardiac rehabilitation program versus coronary revascularization in patients with stable coronary artery disease

1. To compare the impact of a 12-month cardiac rehabilitation program (PRO-FIT) vs. an invasive approach including coronary angiography and subsequent coronary revascularization in stable angina pectoris patients on angina symptoms.2. To evaluate…