46 results
Primary: To explore the diagnostic value to distinguish PAF and MSA of a variety of tests: corneal confocal microscopy optical coherence tomography (OCT) to measure the retinal nerve fibre layer thickness and total macular volume, corneal…
2.1 Primary objectives2.1.1 Cross-sectional part• Technical evaluation of the functional and structural outcome measures to support a biomarker qualification by regulatory authorities and payers. 2.1.2 Longitudinal part • Assessment of prognostic…
An information campaign was developed targeting early-stage KHOA patients and healthcare professionals (HCPs) to optimise timing of referral to secondary care.
To determine the clinical effectiveness of adjuvant therapy given to all unstaged (no lymph node dissection) high risk stage 1 endometrial cancer, compared with only node positive (staged) cases as judged by fulllymph node dissection.
Primary objective: -To assess the predictive value of post-PCI RFR (resting full-cycle ratio) and FFR (fractional flow reserve) with regard to SSR (suboptimal stent result) in CTO (chronic total occlusion) patients. Secondary objectives:- To assess…
The study is intended to determine the performance of a QuantiFERON SARS-CoV-2 test that QIAGEN will bring to the diagnostic market. The proposed study will contribute to establishing the diagnostic parameters such as specificity, sensitivity and…
The current study*s primary aim is to test how trauma-focused therapy affects PTSD symptom-specific neural activity, and investigate neural markers that may predict treatment response to trauma-focused exposure. Furthermore, it is expected that…
The current study aims to elucidate neural correlates of pain processing and dissociative analgesia in PTSD. To this end, we want to replicate the pilot study by Mickleborough et al., (2011) and test the functional pain processing protocol with…
The aim of this study is twofold: 1) to measure ROTEM profiles in patients at risk for DIC to determine cut off values of ROTEM corresponding to the currently used International Society for Thrombosis and Haemostasis (ISTH) DIC scores, as well as to…
This study has been transitioned to CTIS with ID 2023-503793-20-00 check the CTIS register for the current data. The main purpose of this study is to learn whether asundexian works better than placebo at reducing ischemic strokes in participants who…
This study has been transitioned to CTIS with ID 2024-510729-24-00 check the CTIS register for the current data. Primary Objective• To evaluate the efficacy of eptinezumab as add-on to BI for the prevention of migraine and treatment of MOHSecondary…
Our primary objective is to determine how often and to what extent potentially pre-malignant oral fields extend beyond their visible lesion. If those "underestimated" lesions have a greater chance to recur, narrow band imaging-guided…
Primary: to investigate the effectiveness of using Hospital Fit as part of the physiotherapy treatment on average time spent walking per day in patients hospitalised at the Medical Oncology or Cardiology Departments of the Maastricht University…
Zie pagina 14 research protocol
The primary aim of this research is to test the psychometric qualities of the Dutch translation of the CAI-NL. The secondary aim of the study is to evaluate the clinical value of the CAI-NL as an instrument in the treatment of people with severe…
To determine markers related to early ageing and senescence in AYA cancer patients before and after systemic therapy, in order to assess treatment-related early vascular ageing and associated tumour and patient characteristics.
1. To report the natural history of retinal degenaration in patients with biallelic mutations in the PCDH15 gene.2. To identify sensitive structural and functional outcome measures to use for future multicenter clinical trials in PCDH15-related…
The aim of this study is to validate the accuracy of SNNS for the detection of tumor-positive LNs using lymphoscintigraphy with radioactive tracer and NIR with ICG in patients with early EAC with regional LN involvement (clinically staged as T1N1).
To compare a strategy using high PEEP (10 cmH2O) with recruitment maneuvers versus low PEEP (5 cmH2O) without recruitment maneuvers, during thoracic surgery under standardized one lung ventilation with low VT (5 mL/kg predicted body weight - PBW) in…
To assess the following research questions: 1. Does the use of 3D virtual preoperative planning of surgery improve functional outcome as measured by Patient-Reported Outcome in comparison to conventional surgery (using conventional radiographs and/…