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Development of novel clinical endpoints for interventional clinical trials with a regulatory and patient access intention in patients with intermediate age-related macular degeneration (AMD) - MACUSTAR

2.1 Primary objectives2.1.1 Cross-sectional part• Technical evaluation of the functional and structural outcome measures to support a biomarker qualification by regulatory authorities and payers. 2.1.2 Longitudinal part • Assessment of prognostic…

Becker Muscular Dystrophy: analysis of diversity in disease severity

1. To investigate the possible relationship between amount of dystrophin expression and clinical severity of BMD2. To investigate the relationship between specific BMD-gene mutations and clinical severity of BMD3. To investigate possible other…

Short and long term effects of clinical DBT-PE for patients with severe posttraumatic stress disorder and co-morbid psychopathology

The current study aims to determine the effect of a 12-week residential DBT-PE program on a range of different outcomes, including the severity of PTSD, dissociation, personality disorders, and social functioning; The study also aims to predict…

Transfer of feces in ulcerative colitis 2; improving efficacy

To study the efficacy and safety of FMT augmented by donor selection and repetitive dual route administration.To study microbiota composition, functional and metabolic changes as a result of dietary modulation and FMT.

The effects of antipsychotic maintenance therapy on brain volume: randomized (dis)continuation after remission of a first psychotic episode.

The aim of the proposed study is to investigate the effects of antipsychotic medication on total brain volume and specific brain structures known to be affected in schizophrenia, such as hippocampus, thalamus, caudate, parietal and prefrontal cortex…

Understanding B cell biology in auto-immune diseases.

Aim of the studyWe intend to study in detail the different aspects of B cell biology in the auto-immune diseases outlined above. With the sample material obtained from patients (see below), we will be able to analyze (auto-reactive) B cells and…

Wheezing Illnesses Study Leidsche Rijn/ Adolescents

Primary objectives are displayed here.Part 1: Establish the effect of early life cardiovascular risk factors on pre-clinical atherosclerosis in adolescents.Part 2: Identify the impact of diminished early life lung function on lung function during…

'Study on infant Adiposity development To Understand the Role of early life Nutrition - the Sophia Saturn Study'

Primary Objective:To investigate change in fat mass index between 6 and 12 months of age in infants receiving Nuturis® formula feeding versus standard formula feeding during the first 6 months of life.Secondary Objectives:- To investigate change in…

European trial on Optical Coherence Tomography Optimized Bifurcation Event Reduction

Compare median two-year clinical outcome after OCT guided vs. standard guided revascularization of patients requiring complex bifurcation treatment.

Open-label, multicenter study of the 18F labeled PET/CT (positron emission tomography / computed tomography) tracer BAY 86-9596 following a single intravenous administration of 200 or 300 MBq (corresponding to <= 18 µg mass dose), for evaluation of radiation dosimetry, plasma pharmacokinetics, safety and tolerability in healthy volunteers (200 MBq) as well as investigation of safety, tolerability and diagnostic performance in patients (300 MBq) with non small cell long cancer, breast cancer, hea

Primary objective:Explorative investigation of the tumor detection rate with BAY 86-9596 in comparison to that of 18F-fluorodeoxyglucose (FDG)Secondary objectives:- Determination of radiation dosimetry and pharmacokinetics of BAY 86-9596 in healthy…