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Costs of Implant-supported Over-Dentures (IOD) can be halved using a digital workflow

Our goal is to manufacture a 3D-IOD which is designed digitally, and subsequently 3D-printed. Such 3D-IOD, can be made cheaper, faster and more patient friendly. To prove such a statement, patients should at least be even satisfied about their 3D-…

STATEC: A randomised trial of non-selective versus selective adjuvant therapy in high risk apparent stage I endometrial cancer

To determine the clinical effectiveness of adjuvant therapy given to all unstaged (no lymph node dissection) high risk stage 1 endometrial cancer, compared with only node positive (staged) cases as judged by fulllymph node dissection.

Gut Microbiome Analysis in de Novo Parkinson's Patients

The primary objective of this study is to determine the relative contributions of PD diagnosis and dopaminergic medication use to the changes in microbiota composition observed in PD patients. Secondary objectives are to determine the relative…

Nocturnal Non-Invasive ventilation in COPD patients with stable hypercapnic respiratory failure: why and in which patient might this be effective?

Objectives: 1) To investigate change in FEV1 after 3 months nocturnal NIV in stable hypercapnic COPd patients as compared to standard care2) To investigate the relationship between FEV1 change and modification of systemic and airway inflammation and…

Comparison of multiple breath washout and particles in exhaled air for assessment of small airway function in children with cystic fibrosis

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PROtective ventilation with high versus low PEEP during one-lung ventilation for THORacic surgery - PROTHOR: A randomized controlled trial

To compare a strategy using high PEEP (10 cmH2O) with recruitment maneuvers versus low PEEP (5 cmH2O) without recruitment maneuvers, during thoracic surgery under standardized one lung ventilation with low VT (5 mL/kg predicted body weight - PBW) in…