1372 results
1. Immunology and Pathology:To determine the immune response of patients with simple and complex appendicitis in order to identify markers which distinguish between simple and complex appendicitis.2.Clinical and Imaging:To analyze the differences in…
To improve the response rate to treatment of severe acute GVHD (grade II-IV with gut involvement ) by adding infusion of Mesenchymal Stroma Cells to standard high dose prednisolone.
We have developed the TES program, which involves Targeted selection and Enhanced care, delivered on the basis of Stepped care (TES). The primary study aim is to evaluate the effectiveness of the TES-program compared to usual care in reducing…
To investigate lesion detection in patients with liver metastases of colorectal cancer with [18F] FLT-PET compared to CT at baseline (= gold standard). This investigation will be done based on a qualitative assessment of the scans ([18F] FLT-PET and…
The objective is to compare the efficacy and safety of masitinib 12 mg/kg/day to sinutinib 50 mg/day
Within this project we aim to determine the energetic conditions that underlie the transition to hypertrophy of the HOCM heart. A prospective comparison will be made between results of PET, MRI and function of cardiac myofilaments (in vitro). Also,…
Primary Objective: To gain more insight in the genetic susceptibility for AIH. For this we will study the presence of candidate genes in AIH patients, study genetic similarities with other auto-immune diseases and perform a whole genome association…
Determining the role and influence of genetics, their polymorphisms and immunologic phenotype in arteriogenesis in patients with obstructive coronary artery disease (CAD).
De lnternational CIDP Outcome Study (ICOS) aims to describe in detail the variation in clinical and electrophysiological subtypes, current practice of treatment, clinical course and outcom in CIDP. The second objective is to define the clinical and…
Primary objectives: Evaluation of the efficacy of imiquimod 5% cream compared to treatment with Large Loop excision of the transformation zone (LLETZ) for recurrent/residual CIN.Secondary objectives: evaluation of the effect of treatments on HPV DNA…
Primary objective:To observe an increase in Overall Response Rate (ORR) from 20% in the pembrolizumab alone arm to 50% in the pembrolizumab after SBRT arm at 12 weeks. Secondary Objective: - Disease Control Rate, defined as the percentage of…
Evaluate the safety and effectiveness of four cementless Taperloc versions: Taperloc Complete Reduced Distal and Taperloc Legacy Full Profile Reduced Distal compared to Taperloc Complete Full Profile and Taperloc Legacy Full Profile in primary THA.
The main objective of this study is to investigate the effectiveness of the humeral immune response after influenza revaccination in patients with MG with acetylcholine antibodies (AChR MG). The secondary objectives are to determine if vaccination…
To determine the mechanism of action of propranolol in the prophylactic treatment of migraine.
The primary objective is to determine the safety and tolerability BCG vaccination followed by controlled human malaria infection; and to determine the protective efficacy BCG vaccination against a controlled human malaria infection.
The aim of the study is to compare the radiological outcome of three different biocomposite interference screws (BIS) in two different ACL-reconstruction techniques with reference to TW, absorption and clinical follow up after three years.
4.1 Primary• To estimate the Sensitivity and False Positive rate of OTL38 for malignancy detection during Near Infrared Imaging (NIR).• To assess the safety and tolerability of single intravenous doses of OTL384.2 Secondary• To assess the safety of…
The main aim of the EuroFIT trial is to assess the effectiveness and cost-effectiveness of the EuroFIT programme in supporting men to achieve an increase of at least 1000 steps per day (about 10 minutes on average per day, or 70 minutes per week)…
Efficacy and safety trial with S 44819 after recent ischemic cerebral Event
Primary objective: To study the faesibility of SLNM in patients with histological proven colon cancer using NIR-laparoscopy.Secondary objectives: To study the incidence of micrometastasis with the use of ICG and RT-PCRTo determine the number of…