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Dual sensory impairment in the older patient: a randomized controlled trial to the effectiveness of a Dual Sensory Loss-protocol

The objective of this study is to develop and test a DSL-protocol which will focus on proper use of hearing-aids, and will also provide patients (and their significant others) with specific skills to improve the use of the senses and communication.…

Elderly patients suspected of cognitive decline by family physicians; a cluster randomized controlled trial to improve the diagnostic and care process

To evaluate the feasibility and (cost) effectiveness of an intervention to improve the quality of dementia care and the wellbeing of home dwelling persons with dementia and their main informal caregiver.

The Cost4visit Study

We hypothesize that video consultations will be valued equivalent with F2F-visits, with a reduction in associated patient costs and total healthcare costs. In addition to that, we hypothesize that patients consider F2F-visits worth the effort and…

Self-management of persons with advanced cancer and their relatives (SMART): the Living with Cancer Programme

To evaluate the effectiveness of a peer-led, video-based self-management support programme for patients with advanced cancer and their relatives. The programme aims to improve the wellbeing of patients with advanced cancer and their relatives,…

Mechanical insufflation-exsufflation (Cough Assist) in Critically Ill Adults: A randomized controlled trial

The primary objective of this study is to evaluate the feasibility of MI-E in invasively ventilated critically ill patients. The secondary objective is to evaluate safety and explore data on the efficacy of MI-E in invasively ventilated critically…

A pilot randomized controlled trial investigating the feasibility, acceptability and preliminary (cost-)effectiveness and implementation of a combined lifestyle intervention for outpatients with a severe or chronic psychiatric illness (CHAPTER)

The objective of the study is to investigate the feasibilty, acceptabilty, implementation and preliminary (cost-)effectiveness of the intervention on recovery, health and lifestyle variables.

Randomized phase III study comparing a non-myeloablative lymphocyte depleting regimen of chemotherapy followed by infusion of tumor infiltrating lymphocytes and interleukin-2 to standard ipilimumab treatment in metastatic melanoma

In this randomized controlled phase III study we will evaluate whether TIL infusion preceded by non-myeloablative chemotherapy and followed by high dose bolus interleukin-2 can result in an improved progression free survival when randomly compared…

Difference in patellar tracking before and after Journey II BCS total knee arthroplasty, evaluated with 4D CT imaging

The current proposal aims to investigate the patellar tracking in patients receiving Journey II BCS total knee arthroplasty before and one year after surgery, positioned with the CORI instrumentation. The hypothesis is that less change in patella…

Virtual Pain Care; The effectiveness of Virtual Reality Therapy on reducing pain, and anxiety during complex wound care procedures in adults

To assess whether the use of Virtual Reality Therapy can reduce pain, and anxiety than without Virtual Reality Therapy in patients undergoing complex wound care procedures.