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Does High Flow Nasal Cannula (HFNC) facilitate CO2-washout during EBUS under procedural sedation?

The objective is to investigate if there is a flow-dependent effect of HFNC on ventilation during an EBUS procedure under procedural sedation in patients with COPD gold class 3-4.

Efficacy of repetitive transcranial magnetic stimulation in patients with medication-resistant bipolar depression. A multicenter, randomized, double-blind, sham-controlled study

Objective: We want to determine the effectiveness of rTMS in patients with bipolar depression who did not respond to two or more adequately dosed medication trials, using an adequately powered pragmatic RCT. We hypothesize that active rTMS, compared…

Personalized tacrolimus treatment for pediatric kidney transplant recipients by using a dosing algorithm and a once-daily tacrolimus formulation.

This study has been transitioned to CTIS with ID 2024-511585-36-00 check the CTIS register for the current data. The key objective is to personalize tacrolimus treatment for children with a renal transplant by using dosing algorithms to calculate…

A Phase 3b/4 Randomized, Blinded, Treat-to-Target and Dose-Flexibility Study of Upadacitinib in Adult Subjects with Moderate to Severe Atopic Dermatitis

This study has been transitioned to CTIS with ID 2023-504869-23-00 check the CTIS register for the current data. 1. Sub-Study 1 (SS1): The primary study objective for SS1 is to evaluate the efficacy and safety of dose escalation to upadacitinib 30…

*Prevention of opioid-induced constipation in patients with advanced cancer*

This study has been transitioned to CTIS with ID 2023-509462-38-00 check the CTIS register for the current data. Primary Objective: In patients with advanced cancer, starting with opioids for pain: • To prove non-inferiority of magnesium hydroxide…

The effect of diet interventions on quality of life in women with endometriosis related pain symptoms:
the Anti-Inflammatory Diet in Endometriosis (AIDEN) study

The primary objective is to investigate the effect of an anti-inflammatory diet on HRQoL and pain symptoms in women with endometriosis. The secondary objective is to investigate the effect of an anti-inflammatory diet on inflammatory characteristics…

Deep versus moderate neuromuscular blockade during total hip replacement surgery to improve postoperative quality of recovery and immune function: a randomized controlled study

The main objective of this study is to assess the potential effect of deep neuromuscular blockade on the quality of recovery after total hip replacement surgery under general anesthesia. Secondary aims are to establish the relationship between the…

A multicenter study of secukinumab, with a randomized double-blind, placebo-controlled withdrawal-retreatment period, to evaluate maintenance of response in participants with non-radiographic axial spondyloarthritis who achieved remission

This study has been transitioned to CTIS with ID 2023-509320-17-00 check the CTIS register for the current data. * To evaluate whether continuous secukinumab treatment is superior to placebo in preventing flares during Treatment Period 2 in…

An open-label, single-center, exploratory study of the safety and efficacy of avalglucosidase alfa in patients with non-classic Pompe disease aged >= 5 years.

This study has been transitioned to CTIS with ID 2024-518215-18-00 check the CTIS register for the current data. To explore safety, tolerability and efficacy of avalglucosidase alfa in previously treated alglucosidase alfa late-onset Pompe disease…