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A Randomized, Double-Blind, Placebo-Controlled Study of Galcanezumab in Adolescent Patients 12 to 17 Years of Age with Chronic Migraine - the REBUILD-2

This study has been transitioned to CTIS with ID 2023-505835-11-00 check the CTIS register for the current data. PrimaryTo demonstrate the superiority of galcanezumab versus placebo in the prevention of migraine in an adolescent population (12 to 17…

Genetic Clopidogrel response testing to finetune the antithrombotic regimen in (D)OAC Treated patients undergoing PCI

This study has been transitioned to CTIS with ID 2024-512350-17-01 check the CTIS register for the current data. The aim of this study is to evaluate the feasibility and safety of CYP2C19-genotype-guided p2y12 inhibitor selection in patients who are…

A Randomized, Double-Blind, Placebo-Controlled Study of Galcanezumab in Patients 6 to 17 Years of Age with Episodic Migraine - the REBUILD-1

This study has been transitioned to CTIS with ID 2023-505836-36-00 check the CTIS register for the current data. Main Objective:To demonstrate the superiority of galcanezumab versus placebo in the prevention of migraine in (at least) 1 of the…

Effect of protein supplementation on fat free mass preservation after bariatric surgery, a randomized double-blind placebo-controlled trial.

The main aim of this study is to assess whether protein supplementation could prevent excessive fat free mass loss during the first year after bariatric surgery.

Phase 2, Multicenter, Randomized, Parallel, 3-arm, Placebo-controlled Study to Assess Efficacy and Safety of CDR132L in Patients with Reduced Left Ventricular Ejection Fraction (<= 45%) After Myocardial Infarction (HF-REVERT)

This study has been transitioned to CTIS with ID 2023-507569-24-00 check the CTIS register for the current data. This is a Phase 2, multicenter, randomized, parallel, 3-arm, placebo-controlled study to assess theefficacy and safety of CDR132L in…

*Prevention of opioid-induced constipation in patients with advanced cancer*

This study has been transitioned to CTIS with ID 2023-509462-38-00 check the CTIS register for the current data. Primary Objective: In patients with advanced cancer, starting with opioids for pain: • To prove non-inferiority of magnesium hydroxide…

The effect of diet interventions on quality of life in women with endometriosis related pain symptoms:
the Anti-Inflammatory Diet in Endometriosis (AIDEN) study

The primary objective is to investigate the effect of an anti-inflammatory diet on HRQoL and pain symptoms in women with endometriosis. The secondary objective is to investigate the effect of an anti-inflammatory diet on inflammatory characteristics…

*A Positive Psychology Intervention for Cardiovascular Patients: a Single Case Experimental Design*

To examine whether the Positive Psychology group intervention *Goed leven met een hartaandoening* [Living well with heart disorder] is effective in increasing mental well-being, ability to adapt, positive skills (e.g. savouring, positive re-…

Longer-term effects of peanut consumption on brain function in older men and women.

The primary objectives are to investigate in older men and women the effect of 16-week peanut consumption on brain vascular function and brain insulin-sensitivity in cognitive-control brain areas, while we will also focus on changes in cognitive…

Ototoxicity in patients with Metal-on-Metal hip Arthroplasties

To evaluate the prevalence of ocular-vestibular symptoms in patients with a (revised) MoM hip prosthesis. Our hypothesis is that patients with high plasma metal ion levels have a higher prevalence of damage to the auditory system.