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*Energetics in hypertrophic cardiomyopathy: translation between PET, MRI and cardiac myofilament function*

Within this project we aim to determine the energetic conditions that underlie the transition to hypertrophy of the HOCM heart. A prospective comparison will be made between results of PET, MRI and function of cardiac myofilaments (in vitro). Also,…

Phase III Randomized Double-Blind Trial of Bepanthen® Cream Versus Cetomacrogol Cream in the Prevention of Papulopustular eruption in Patients Receiving Epidermal Growth Factor Receptor Inhibitors (EGFRI): BeCet

To assess the preemptive effect of Bepanthen® on decreasing the incidence of specific >= grade 2 dermatological side effects of interest in respect of compliance to EGFRI agents, HRQoL and the adherence during the 6-week skin treatment period…

Gender identity, sex hormones & the developing brain

To compare sex differences in brain functioning using functional magnetic resonance imaging (fMRI) in healthy pre-pubertal boys and girls with a group of children diagnosed with GID. Subjects will have a second fMRI scan, as soon as they enter…

Ultrasound-guided breast-sparing surgery to improve cosmetic outcomes and quality of life.

To reduce the extent of healthy breast tissue resection by US-guided surgery for palpable tumours compared to traditional palpation-guided surgery, without compromising oncological principles. To improve cosmetic outcomes and quality of life by US-…

Randomised, double-blind, placebo-controlled single ascending dose study investigating the safety, tolerability, pharmacokinetic and pharmacodynamic properties of the research medication in healthy young and elderly men, and open-label three-period crossover food interaction study of the research medication in healthy elderly men

- to examine the safety and tolerability of the research medication- to examine how the research medication is absorbed, broken down and excreted by the body.

Treating Stooped Posture in Parkinson's Disease: a pilot study

The objective of this study is testing the efficacy, practical utility and user-friendliness of a trunk angle sensor and feedback device (Parkinson Assist, 2M Engineering Ltd) in the home setting of patients with Parkinson's disease with a…

Fetal brain imaging in fetuses at high risk of acquired anomalies

Applicability of fetal brain imaging techniques for clinical purposes.

Oral COX-2 inhibitor Celecoxib in Peritoneal Dialysis Patients: effects on peritoneal transport and peritoneal defence.

Based on the positive effects of Celecoxib on ultrafiltration and peritoneal injury during PD in rats, we would like to propose a pilot study using Celecoxib in PD-patients. In this pilot study we will investigate whether the Cox2 inhibitor…

PET probe guided extirpation of FDG-PET positive lymph nodes which are negative on other imaging modalities in head and neck cancer patients scheduled for primary irradiation

Feasibility of PET probe guided extirpation of FDG-PET positive lymph nodes which are negative on other imaging modalities in head and neck cancer patients scheduled for primary irradiation.

Identifying genetic and metabolic risk factors for mild non-specific mental retardation and borderline intellectual functioning in parent offspring trios.

The main aim of this project is to identify genetic and metabolic risk factors for mild MR and borderline intelligence.

Towards prediction of speech recognition in cochlear implant users

The primary objective is to investigate the influence of auditory and non-auditory factors on speech recognition abilities in quiet and in noise in CI users. For this reason we will study the effects of linguistic skills and working memory capacity…

Decision-Related Activity in Human Visual Cortex during Perceptual Suppression

To characterize the neural interactions underlying simple perceptual decisions about the target disappearance during motion-induced blindness.

Long term prospective follow-up study of tocilizumab (RoActermraR) administered to patients with rheumatoid arthritis in daily clinical practice.

To determine the efficacy and safety of tocilizumab in the daily clinical practice situation for at least 36 months in comparison to the reported efficacy and safety in clinical trials.There will be a particular focus of the effect of tocilizumab on…

Considering compression after varicose vein surgery; a randomised controlled trial.

"the effects of compression bandages after varicose vein surgery".

Feasibility study for a novel and clinically useful MRI sequence for imaging myelin in MS patients

In 2009, a new combination of MRI sequences was published by Deoni et al. (2009) that promised the ability to measure the myelin water in vivo over the whole head in a clinically useful time. Referred to as mcDespot (multi-component driven…

PRODEO: PROfylactic Haloperidol in patients defined as high risk for DElirium with delirium risk mOdel

Research questionWill prophylactic administration of haloperidol to patients with a high risk of developing a delirium according to DEMO, reduce the incidence of a delirium? HypothesesProphylactic administration of haloperidol in post-operative…

Preservation of ovarian cortex tissue in girls with Turner syndrome:
A multicenter exploratory intervention study

To investigate the occurrence of live birth in women with TS after ovarian tissue cryopreservation in childhood followed by auto transplantation in adulthood.

Sentix: A prospective observational trial on sentinel lymph node biopsy in patients
with early stage cervical cancer

To evaluate whether a less radical surgical approach with sentinel lymph node biopsy is non-inferior to treatment with systematic pelvic lymphadenectomy.The null hypothesis is that the recurrence rate after SLN biopsy is non-inferior to the…

Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication

Primary objective* To evaluate the efficacy in terms of overall survival (OS) of erlotinib, everolimus and dasatinib in combination with radiation therapy, in patients with a DIPG both: - compared to the other experimental treatments by comparisons…

A Phase 3, Randomized, Open-Label Study Evaluating the Efficacy of Axicabtagene Ciloleucel versus Standard of Care Therapy in Subjects with Relapsed/Refractory Diffuse Large B Cell Lymphoma (ZUMA-7)

Primary Objective- To determine if axicabtagene ciloleucel is superior to SOC as measured by event-free survival (EFS), as determined by blinded central reviewSecondary Objectives- To evaluate the effect of axicabtagene ciloleucel compared to SOC on…