61 results
Within this project we aim to determine the energetic conditions that underlie the transition to hypertrophy of the HOCM heart. A prospective comparison will be made between results of PET, MRI and function of cardiac myofilaments (in vitro). Also,…
To assess the preemptive effect of Bepanthen® on decreasing the incidence of specific >= grade 2 dermatological side effects of interest in respect of compliance to EGFRI agents, HRQoL and the adherence during the 6-week skin treatment period…
To compare sex differences in brain functioning using functional magnetic resonance imaging (fMRI) in healthy pre-pubertal boys and girls with a group of children diagnosed with GID. Subjects will have a second fMRI scan, as soon as they enter…
To reduce the extent of healthy breast tissue resection by US-guided surgery for palpable tumours compared to traditional palpation-guided surgery, without compromising oncological principles. To improve cosmetic outcomes and quality of life by US-…
- to examine the safety and tolerability of the research medication- to examine how the research medication is absorbed, broken down and excreted by the body.
The objective of this study is testing the efficacy, practical utility and user-friendliness of a trunk angle sensor and feedback device (Parkinson Assist, 2M Engineering Ltd) in the home setting of patients with Parkinson's disease with a…
Applicability of fetal brain imaging techniques for clinical purposes.
Based on the positive effects of Celecoxib on ultrafiltration and peritoneal injury during PD in rats, we would like to propose a pilot study using Celecoxib in PD-patients. In this pilot study we will investigate whether the Cox2 inhibitor…
Feasibility of PET probe guided extirpation of FDG-PET positive lymph nodes which are negative on other imaging modalities in head and neck cancer patients scheduled for primary irradiation.
The main aim of this project is to identify genetic and metabolic risk factors for mild MR and borderline intelligence.
The primary objective is to investigate the influence of auditory and non-auditory factors on speech recognition abilities in quiet and in noise in CI users. For this reason we will study the effects of linguistic skills and working memory capacity…
To characterize the neural interactions underlying simple perceptual decisions about the target disappearance during motion-induced blindness.
To determine the efficacy and safety of tocilizumab in the daily clinical practice situation for at least 36 months in comparison to the reported efficacy and safety in clinical trials.There will be a particular focus of the effect of tocilizumab on…
"the effects of compression bandages after varicose vein surgery".
In 2009, a new combination of MRI sequences was published by Deoni et al. (2009) that promised the ability to measure the myelin water in vivo over the whole head in a clinically useful time. Referred to as mcDespot (multi-component driven…
We hypothesize that video consultations will be valued equivalent with F2F-visits, with a reduction in associated patient costs and total healthcare costs. In addition to that, we hypothesize that patients consider F2F-visits worth the effort and…
To investigate the effect of banded sleeve gastrectomy
The overall goal of this study is to assess the detection and discrimination of individual silently or attempted spoken words from the brain area that represents articulation of speech.To address this goal, we defined three primary objectives:1) To…
This study aims to isolate and culture myogenic stem cells called mesoangioblasts from the muscle biopsies to explore if genetic correction of LAMA2 mutations using CRISPR-Cas9 can be achieved and subsequently assess the effect in vitro, as a first…
This protocol describes a framework that will be used to create multiple studies, which are based on the secondary objectives. The outcomes of the studies together will provide more insight in the primary objective. Primary Objective: Investigate…