32 results
We have developed the TES program, which involves Targeted selection and Enhanced care, delivered on the basis of Stepped care (TES). The primary study aim is to evaluate the effectiveness of the TES-program compared to usual care in reducing…
Aim of this study is to investigate the tolerance and the outcome of extreme hypofractionated RT for prostate cancer by delivering a high dose using two alternative time schedules, a short and long treatment interval.
The primary objective of this study is to document the incidence of unanticipated device and procedure related adverse events intra-operatively and through one year follow-up.
Objective 1: To improve clinical practice in the management of disorders of sex development (DSD)Objective 2: To develop accepted evidence-based clinical guidelines for a better clinical care of patients with DSD affected by distinct genetic…
The primary objective of the study is to examine muscle atrophy in fetuses with single or bilateral IPEV, in comparison to a normal population by measuring the circumference of the upper and lower legs by ultrasound examination. The length of the…
Primary Objective: To investigate whether population screening for increased albuminuria among the Dutch population can contribute to the early detection of yet undiagnosed risk factors for renal and cardiovascular diseases in an early stage. For…
With this study, we aim to shed light on the possible use of diagnostic next generation sequencing in DLD, by determining the diagnostic yield of WGS in this important class of neurodevelopmental disorder. In addition to determining this diagnostic…
The objective of this study is to accurately assess and compare migration, clinical and radiological outcome and patient reported outcomes of two TKR prostheses: the Cemented ATTUNE (S+Tibia component) Fixed Bearing Cruciate Retaining Knee System…
This study aims to underpin the delivery of longstanding exercise therapy in the subgroup of patients with RA and complex disability.There are 2 research questions to be addressed 1. Is longstanding, optimized active exercise therapy more effective…
Primary objective: To investigate the feasibility of a program for functional remediation for patients with BD-I or recurrent MDD, through • Evaluation of user experiences with the program. • Evaluation of drop-out and reasons for drop-out. •…
This study aims to underpin the delivery of longstanding exercise therapy in the subgroup of patients with axSpA and complex disability.There are 2 research questions to be addressed 1. Is longstanding, optimized active exercise therapy more…
The objective of this study is to evaluate the efficacy and safety of cabozantinib in combination with nivolumab and ipilimumab versus nivolumab and ipilimumab in previously untreated subjects with intermediate- and poor-risk advanced or metastatic…
Aim of this assessment is to explore the course (persistence, remission and onset) of AH and to investigate associations with other psychic experiences, anxiety and depressive symptoms, risk factors (trauma, cannabis), protective factors (coping…
This prospective evaluation of the dynamics of thyroid hormones during cancer treatment in children is designed to determine the prevalence of thyroid hormone deficits at diagnosis, during and directly after treatment and to study changes in thyroid…
Primary objective:To estimate the efficacy of adjuvant nivolumab monotherapy in completely resected MCC patients; i.e. the primary endpoint is Disease-free survival (DFS) in arm A at 12 months, defined as the number of patients alive and free of…
The primary objective of the study is to evaluate the safety and tolerability of the Occlutech® AFR device by assessing the incidence of SADEs in the 3 months following implantation. Secondary objectives are related to safety and efficacy:• To…
1. To investigate the glucose and insulin responses after the MTT enriched with labelled glucose early (12-16 weeks), mid pregnancy (24-28 weeks) and postpartum (3 months) 2. Compare the MTT results with the standard OGTT testing at 24-28 weeks (in…
The primary objective is to investigate if ADT can increase the uptake of 68Ga-PSMA in patients with R/M SDC.
The primary objectives are:- To evaluate the safety and tolerability of IT administration of CyPep-1 as monotherapy and in combination with pembrolizumab.- To identify the recommended phase II dose (RP2D) of CyPep-1 as monotherapy and in combination…
Primary Objective: To determine the (cost)effectiveness of 5-fluorouracil cream (5FU) and photodynamic therapy (PDT), compared to surgical excision (SE) in Bowen*s Disease (BD).Secondary Objectives: To determine the (cost)effectiveness of 5-…