155 results
The primary objective of the study is to examine muscle atrophy in fetuses with single or bilateral IPEV, in comparison to a normal population by measuring the circumference of the upper and lower legs by ultrasound examination. The length of the…
Primary Objective: To investigate whether population screening for increased albuminuria among the Dutch population can contribute to the early detection of yet undiagnosed risk factors for renal and cardiovascular diseases in an early stage. For…
With this study, we aim to shed light on the possible use of diagnostic next generation sequencing in DLD, by determining the diagnostic yield of WGS in this important class of neurodevelopmental disorder. In addition to determining this diagnostic…
The objective of this study is to accurately assess and compare migration, clinical and radiological outcome and patient reported outcomes of two TKR prostheses: the Cemented ATTUNE (S+Tibia component) Fixed Bearing Cruciate Retaining Knee System…
This study aims to underpin the delivery of longstanding exercise therapy in the subgroup of patients with RA and complex disability.There are 2 research questions to be addressed 1. Is longstanding, optimized active exercise therapy more effective…
Primary Objective:1) Assess different LV loading mechanisms in Barlow's Disease (BD) versus Fibroelastic deficiency (FED), including transvalvular mitral regurgitant and prolapse volume, both with echocardiography and cardiac magnetic resonance…
Primary objective: To investigate the feasibility of a program for functional remediation for patients with BD-I or recurrent MDD, through • Evaluation of user experiences with the program. • Evaluation of drop-out and reasons for drop-out. •…
This study aims to underpin the delivery of longstanding exercise therapy in the subgroup of patients with axSpA and complex disability.There are 2 research questions to be addressed 1. Is longstanding, optimized active exercise therapy more…
The objective of this study is to evaluate the efficacy and safety of cabozantinib in combination with nivolumab and ipilimumab versus nivolumab and ipilimumab in previously untreated subjects with intermediate- and poor-risk advanced or metastatic…
Aim of this assessment is to explore the course (persistence, remission and onset) of AH and to investigate associations with other psychic experiences, anxiety and depressive symptoms, risk factors (trauma, cannabis), protective factors (coping…
This prospective evaluation of the dynamics of thyroid hormones during cancer treatment in children is designed to determine the prevalence of thyroid hormone deficits at diagnosis, during and directly after treatment and to study changes in thyroid…
Primary objective:To estimate the efficacy of adjuvant nivolumab monotherapy in completely resected MCC patients; i.e. the primary endpoint is Disease-free survival (DFS) in arm A at 12 months, defined as the number of patients alive and free of…
The primary objective of the study is to evaluate the safety and tolerability of the Occlutech® AFR device by assessing the incidence of SADEs in the 3 months following implantation. Secondary objectives are related to safety and efficacy:• To…
1. To investigate the glucose and insulin responses after the MTT enriched with labelled glucose early (12-16 weeks), mid pregnancy (24-28 weeks) and postpartum (3 months) 2. Compare the MTT results with the standard OGTT testing at 24-28 weeks (in…
The primary objective is to investigate if ADT can increase the uptake of 68Ga-PSMA in patients with R/M SDC.
To determine the potential impact of ball heading in football on brain integrity as assessed by blood biomarkers for neural damage in a real-world setting.
This study has been transitioned to CTIS with ID 2024-513392-40-01 check the CTIS register for the current data. The design will be a prospective, single center phase I feasibility and dose finding study in patients with high-grade glioma, to…
The primary objective is to determine whether there is a difference in the capability of the patients to successfully follow the instructions of both the Levodopa Cyclops* and the INBRIJA® inhaler during an off episode, based on the instruction…
To evaluate how the 3D knee joint space distribution in knee OA patients changes under the influence of weight-bearing (upright) and flexion MRI scanning.
Investigation of pelvic blood circulation by MRI in women with a gynaecological cancer who will have curative radiotherapy with or without weekly HT for inoperable pelvic tumours.