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Results of the Anser Clavicle Pin for treatment of Midshaft Clavicle Fractures

The goals of this study are to evaluate the union rate, patient satisfaction and functional results of the Anser Clavicle Pin in a larger cohort then approved in the study, Anser; A novel intramedullary device for fixation of midshaft clavicle…

89Zr-Bevacizumab PET/CT imaging of vestibular schwannomas for the prediction of bevacizumab treatment effect in patients with symptomatic neurofibromatosis type 2.

This study has been transitioned to CTIS with ID 2024-512860-75-00 check the CTIS register for the current data. The aim of this feasibility study is to validate pre-treatment [89Zr]-bevacizumab PET/CT as an imaging biomarker for prediction of…

Pamidronate for pain in adult chronic nonbacterial osteitis (PAM-CNO): a randomized, double-blind, placebo-controlled trial

This study has been transitioned to CTIS with ID 2023-510309-16-00 check the CTIS register for the current data. The primary objective to demonstrate that in CNOpatients with pain 3-monthly treatment with pamidronate will result in significant…

Comparison of clinical and radiographical outcomes following placement of hybrid and moderate rough implants in the posterior mandible of periodontally compromised patients: a 3-year randomized clinical trial

Thel aim of this project is to analyse hybrid implants placed in de posterior mandible of periodontally compromised patients and to compare the treatment outcome of either moderate rough or hybrid implants.

A Long-term Follow-up Study to Evaluate the Safety and Efficacy of RGX-501

The primary study objective is long-term safety of RGX-501 and secondarily evaluation of the long-term effects of RGX-501 on LDL-C and other lipid parameters.

The effect of Eye Movement Desensitisation and Reprocessing (EMDR) on abdominal pain in patients with Irritable Bowel Syndrome (IBS).

Our goal is to investigate the effect of EMDR treatment on abdominal pain in patiënts with Irritable Bowel Syndrome. In addition we will investigate the effect of EMDR treatment on other IBS physical complaints and on patients' experienced…

99mTechnetium based PSMA-Radioguided Assisted surgery for prostate Cancer feasibility Study

The potential use of 99mTechnetium (99mTc)-based PSMA-radioguided surgery (99mTc-PSMA-RGS) for salvage lymphadenectomy for PC.

Tailored lymphadenectomy using Sentinel node Navigation surgery in high-risk (sub)mucosal esophageal Adenocarcinoma Patients: SNAP-III study

The aim of this study is to evaluate the feasibility and safety of new esophageal preserving treatment algorithm for patients with high-risk T1a or T1b EAC consisting of radical ER of the tumor, followed by a SNNS procedure with selective…

Exploratory study into the effect of salt supplementation in Gitelman syndrome

To determine the effect of salt (NaCl) supplementation on (1) physiological parameters (such as serum potassium) and on (2) clinical signs and symptoms and quality of life.

Effectiveness of EMDR for adolescents with Major Depressive Disorder

This study aims to investigate the effectiveness of EMDR (n=32) in comparison to a waiting list in (n=32) adolescents (12-18 years) with a primary diagnosis of MDD (DSM-5; American Psychiatric Association, 2013). It is hypothesized that the…

AN OPEN-LABEL, MULTICENTER STUDY TO INVESTIGATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF RO7248824 IN PARTICIPANTS WITH ANGELMAN SYNDROME

This study has been transitioned to CTIS with ID 2024-514797-45-00 check the CTIS register for the current data. PRIMARY OBJECTIVE: - To assess the (long-term) safety and tolerability profile of RO7248824.SECONDARY OBJECTIVE: - To investigate the…

Pathophysiology of Acute Atrial fibrillation in Obstructive Sleep Apnea

The primary objective is to assess the role of obstructive sleep apnea related pathophysiological mechanisms in the initiation of atrial fibrillation by a multi-parametric strategy that combines the estimated parameters. The main hypothesis is that…

'BATMAN' antibiotics against amyloid angiopathy: a placebo-controlled, randomized, double-blind study of minocycline for sporadic and hereditary cerebral amyloid angiopathy.

To prove in a randomized clinical trial in a translational setting that minocycline treatment (duration 3 months) can decrease markers of neuroinflammation and the gelatinase pathway in the cerebrospinal fluid (CSF) of patients with HCHWA-D (n=30)…

Safety and Performance of Invicta ventricular DF4 leads with active fixation.

Safety and performance of Invicta ventricular DF4 leads with active fixation.

AN OPEN-LABEL, MULTICENTER, PHASE IB STUDY TO EVALUATE SAFETY, PHARMACOKINETICS, PHARMACODYNAMICS, AND PRELIMINARY ANTI-TUMOR ACTIVITY OF RO7122290, A FIBROBLAST ACTIVATION PROTEIN-A (FAP) TARGETED 4-1BB LIGAND (CD137L), IN COMBINATION WITH CIBISATAMAB WITH OBINUTUZUMAB PRE-TREATMENT, IN
PARTICIPANTS WITH PREVIOUSLY TREATED, METASTATIC, MICROSATELLITE-STABLE COLORECTAL ADENOCARCINOMA

Primary(Part I and Part II):- To determine the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) in the QW and/or Q3W regimens of RO7122290 in combination with cibisatamab after pretreatment with obinutuzumab- To characterize the…

A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in participants with nonrelapsing secondary progressive multiple sclerosis

Primary: To determine the efficacy of SAR442168 compared to placebo in delaying disability progression in nrSPMSSecondary: 1. To evaluate safety, tolerability, and efficacy of SAR442168 compared to placebo on clinical endpoints, MRI lesions,…

A Phase 3, Prospective, Multicenter, Double-blind, Double-dummy, Randomized, Active-controlled, Parallel-group, Group-sequential, Adaptive, Event-driven Study to Compare Efficacy, Safety, and Tolerability of Macitentan 75 mg Versus Macitentan 10 mg in Patients with Pulmonary Arterial Hypertension, Followed by an Open-label Treatment Period With Macitentan 75 mg

This study has been transitioned to CTIS with ID 2024-515669-32-00 check the CTIS register for the current data. The purpose of this study is to demonstrate superiority of macitentan 75 milligrams (mg) in prolonging the time to the first clinical…

An Imaging and Cognition Study of Positive Valence Systems in Psychotic Syndromes

To examine the PVS domain, and in particular reward circuits and behaviour, in large genetically informative cohorts comprising 500 individuals (including 125 SCZ patients, 125 BP patients, 125 relatives and 125 controls) already ascertained in the…

Vaccination response to pneumococcal antigen as novel predictor for successful tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia.

To assess whether an adequate response to pneumococcal antigen, as a marker of overall humoral immune system reactivity, predicts sustained TFR. An adequate response to pneumococcal antigen will be defined as achieving anti-pneumococcal IgG levels…

Individual characteristics of COPD patients. Analysis of subtypes based on Western and Chinese diagnostics.

The goal of this research proposal is to identify biological mechanisms and patterns underlying COPD subgroups based on Western clinical variables, TCM symptom patterns and metabolic data.The secondary objectives can be summarized as collecting…