71 results
1. Immunology and Pathology:To determine the immune response of patients with simple and complex appendicitis in order to identify markers which distinguish between simple and complex appendicitis.2.Clinical and Imaging:To analyze the differences in…
Determining the role and influence of genetics, their polymorphisms and immunologic phenotype in arteriogenesis in patients with obstructive coronary artery disease (CAD).
Primary objectives: Evaluation of the efficacy of imiquimod 5% cream compared to treatment with Large Loop excision of the transformation zone (LLETZ) for recurrent/residual CIN.Secondary objectives: evaluation of the effect of treatments on HPV DNA…
The main aim of the EuroFIT trial is to assess the effectiveness and cost-effectiveness of the EuroFIT programme in supporting men to achieve an increase of at least 1000 steps per day (about 10 minutes on average per day, or 70 minutes per week)…
The primary aim of this study is to prospectively assess the incidence of pulmonary embolism in patients undergoing abdominal flap breast reconstruction.
Determine the efficacy of atDCS as compared to ctDCS and sham stimulation in the improvement of executive functioning in PD-MCI.
This study has been transitioned to CTIS with ID 2024-513412-10-00 check the CTIS register for the current data. Phase 1: • To determine the MTD/RP2D regimen of brigatinib monotherapy when administered in pediatric and AYA patients with ALK+ ALCL or…
Fluorescence guided surgery for intra-operative detection of meningioma using Bevacizumab-IRDye800CW
In the present study, we aim to perform a feasibility study with Bevacizumab-IRDye800CW in patients with meningioma who are scheduled for elective surgical resection. The ability of fluorescence imaging to identify residual meningioma tissue that is…
The present project aims to evaluate the effectiveness of a multi-modal, personalized, work-oriented physiotherapy intervention in optimizing work ability (primary outcome) and improving clinical outcomes (secondary outcomes), compared to usual care…
Development of a diagnostic algorithm that will diagnose measles cases and classify (potential) contagiousness of patients following measles infection.
To evaluate the effectiveness of a peer-led, video-based self-management support programme for patients with advanced cancer and their relatives. The programme aims to improve the wellbeing of patients with advanced cancer and their relatives,…
to test the feasibility of the study protocol for operability, intensity and logistics and to test whether the chosen activities can be measured as expected, in order to provide a guideline for testing maximum aerobic capacity and the metabolic…
This study has been transitioned to CTIS with ID 2024-514783-78-00 check the CTIS register for the current data. The aim of this project is to investigate CBD as a new medicine to target the ECS in the reduction of anxiety symptoms. Subsidiary aims…
To determine the sensitivity and specificity of the HINTS+ test in detecting a central cause in patients with acute onset, continuous dizziness in a general ED population, when performed by general neurologists/ED physicians.
This study has been transitioned to CTIS with ID 2024-513924-41-01 check the CTIS register for the current data. The primary objective of this study is to compare effectivity of suboxone and methadone on reducing opioid misuse.Secondary objectives…
The primary objective of the study is to test whether peripheral endothelial function assessed using Laser speckle contrast analysis and CED measured with ICFT are correlated.
Part A: To determine the recommended phase 2 dose and schedule of the RMC-4630 and LY3214996 combination in patients with KRASm advanced CRC, NSCLC and PDAC.Part B: To determine the safety and tolerability of RMC-4630 in combination with LY3214996…
We aim to study individual changes in phenotypic characteristics of cardio-metabolic health, and of cognitive and physical performance over a time span of 11 to 19 years in older individuals previously included in the Leiden Longevity Study. This…
This study has been transitioned to CTIS with ID 2023-509694-22-00 check the CTIS register for the current data. Primary objective: • To evaluate the efficacy of tofacitinib based on remission in pediatric participants with moderately to severely…
Primary Aim: We aim to determine markers for NOX2-mediated insulin-independent glucose uptake signalling pathways, mitochondrial function, myokine secretion both at rest and after a bout of acute exercise in individuals with T1DM and healthy…