107 results
This study has been transitioned to CTIS with ID 2024-513412-10-00 check the CTIS register for the current data. Phase 1: • To determine the MTD/RP2D regimen of brigatinib monotherapy when administered in pediatric and AYA patients with ALK+ ALCL or…
Fluorescence guided surgery for intra-operative detection of meningioma using Bevacizumab-IRDye800CW
In the present study, we aim to perform a feasibility study with Bevacizumab-IRDye800CW in patients with meningioma who are scheduled for elective surgical resection. The ability of fluorescence imaging to identify residual meningioma tissue that is…
The present project aims to evaluate the effectiveness of a multi-modal, personalized, work-oriented physiotherapy intervention in optimizing work ability (primary outcome) and improving clinical outcomes (secondary outcomes), compared to usual care…
Development of a diagnostic algorithm that will diagnose measles cases and classify (potential) contagiousness of patients following measles infection.
To evaluate the effectiveness of a peer-led, video-based self-management support programme for patients with advanced cancer and their relatives. The programme aims to improve the wellbeing of patients with advanced cancer and their relatives,…
To investigate the effect of banded sleeve gastrectomy
The overall goal of this study is to assess the detection and discrimination of individual silently or attempted spoken words from the brain area that represents articulation of speech.To address this goal, we defined three primary objectives:1) To…
This study aims to isolate and culture myogenic stem cells called mesoangioblasts from the muscle biopsies to explore if genetic correction of LAMA2 mutations using CRISPR-Cas9 can be achieved and subsequently assess the effect in vitro, as a first…
This protocol describes a framework that will be used to create multiple studies, which are based on the secondary objectives. The outcomes of the studies together will provide more insight in the primary objective. Primary Objective: Investigate…
The aim is to investigate the effect of a multimodal prehabilitation and rehabilitation program in frail patients of 70 years or older, undergoing elective surgery for non-metastatic CRC on1. One-year mortality 2. Postoperative complications,…
We aim to provide a neurocognitive account of communicative disabilities in patients with autism spectrum disorder (ASD), focussing on shared representations of a communicative context. We expect that ASD patients show impaired shared…
The goal of this study is to directly compare effectiveness of the Captain Morgan technique to the Allis technique in reduction of posterior dislocation of a THP using procedural sedation and analgesia (PSA) in the ER.
The aim of the proposed study is to define optimal treatment for the Lisfranc fracture dislocation, either primary arthrodesis or open reduction and internal fixation, in regard to quality of life, complications, functional outcomes and cost…
The aim of this study is to investigate non-inferiority of rituximab SC 336 mg to rituximab IV 200 mg.
The primary objective of this study is to investigate whether usual care combined with CBT improves QoL in patients undergoing surgery for endometriosis compared to usual care only. Secondary objectives are to investigate whether pain intensity,…
This study has been transitioned to CTIS with ID 2024-512968-57-00 check the CTIS register for the current data. The primary objective of the study is to assess the safety and feasibility of autologous salivary gland stem cell transplantation of the…
to test the feasibility of the study protocol for operability, intensity and logistics and to test whether the chosen activities can be measured as expected, in order to provide a guideline for testing maximum aerobic capacity and the metabolic…
We will evaluate the clinical and cost-effectiveness of the two guideline recommended treatments for patients with persisting shoulder pain over a 12 month time period. Patients will be randomized to a local corticosteroid injection or referral for…
This study has been transitioned to CTIS with ID 2023-507303-55-00 check the CTIS register for the current data. To assess the effect of donanemab versus placebo on clinical progression in participants with early symptomatic AD with demonstrated…
The main objective of the proposed study is to evaluate if the Balanseat (used as intended) is feasible when only minor involvement from a therapist is required, contributes to therapy adherence and improves gait and balance compared to usual daily…