121 results
The objective of this study is to investigate if CEC are elevated in SCD (and if they could therefore serve as a potential tool for assessing SCD activity), and what the relation of CEC is to the patients medical history and to specific laboratory…
The primary aim of this study is to validate a screening instrument for ophthalmologic disorders using full, in depth ophthalmologic assessment as the gold standard. Secondary aims include:* To study the severity and clinical impact of different…
Primary Objective: After ex vivo confirmation that BD injected around LC in a laryngeal surgical specimen is not spreading into tissues beyond the tumor, the detection of SLN by a technique of injecting BD via a flexible laryngoscope using a working…
What is the comparative efficacy and safety between dementia diagnostics in primary care and dementia diagnostics in a memory clinic for older persons with memory complaints?
The primary aim of this study is to develop a machine learning framework to predict major complications after major gastro-intestinal surgery. Secondary aims include combining this framework with point of care ultrasound to determine the best…
Assess the predictive capabilities of LSCI on the effect of endovascular revascularization on the microcirculation of the feet over time and what could this mean for clinical decision-making.
To investigate whether peripheral nerve and muscle ultrasound can be used as reliable diagnostic and monitoring biomarkers of PNS involvement in SCA3. Specifically, we will examine: 1) Whether peripheral nerve and muscle ultrasound are able to…
Primary objective: To assess the validity of US to measure lean mass after weight loss in a population of bariatric surgery patients.Secondary Objectives: • To assess de differences in lean mass between DXA and US in this study compared to the…
(1) to create and train an algorithm to generate synthetic CT images of the craniofacial area(2) to evaluate the resulting synthetic CT images in terms of geometrical accurate visualization of the craniofacial osseous structures compared to the…
The objective of this study is to support the pharma partner*s Phase III trial using Tina-quant Lipoprotein (a) RxDx assay for subject selection and optional batch testing of follow-up samples. This study is carried out to evaluate the performance…
The objective is to identify which eye movement features are sensitive biomarkers for FTD. To answer this question, we will assess which eye movement features dissociate best between healthy controls, patients with FTD (familial and non-familial),…
We aim that by assessing listening effort subjectively with an adaptive categorical listening effort scale (ACALES) we can demonstrate the possibly increased listening effort in tinnitus patients.
The overarching aim of the Axial Involvement in Psoriatic Arthritis (AXIS) study is to systematically evaluate clinical and imaging manifestations indicative of axial involvement in patients with PsA to develop classification criteria and a unified…
The primary objective of this study is to detect HRV patterns which are related to cardiovasculair disease such as permanent atrial fibrillation or (congestive) heart failure using a wearable fitness tracker.
The primary objective of this study is to determine the relation of delta PO2 (PaO2-tcPO2) and delta PCO2 (tcPCO2-cPCO2) levels to sepsis. The secondary aims are to determine the factors that influence delta PO2 and delta PCO2 and to determine the…
The aim of this study is two-fold:1.To elucidate the role of neuroinflammation in FTLD2.To identify biomarkers to predict and monitor disease progression in FTLD3.To differentiate FTLD-TDP from FTLD-tau during life using biomarkers for…
The primary objective of this study is to explore the diagnostic accuracy of MRDTI in the diagnostic management of acute and chronic SVT in a prospective diagnostic proof of concept study. The secondary objectives include optimizing MRDTI sequences…
To assess the effectivity and feasibility of HCV RNA self-testing in reducing the time to diagnosis of HCV re-infection in MSM previously cured of an HCV infection, compared to the current diagnostic standard of care. To evaluate whether the uptake…
Primary objectives• To identify the percentage of patients in which a drug resistant clone can be detected with ctDNA before the emergence of radiological progression.• To determine the success rate of crizotinib and osimertinib combination…
Primary objective: The primary objective of this non-randomized intervention trial is to investigate whether TAVR improves exercise capacity in patients with preserved LVEF and NF/LG or LF/LG severe AS reclassified based on hybrid CT/TTE-derived…