841 results
To assess the long-term safety and tolerability of 35 mg and 70 mg RVT-101 in subjects with DLB
The objectives of this study are to:- Evaluate the safety and tolerability of up to 2 dosing cycles of GemRIS for up to 21 days per dosing cycle.- Evaluate the pharmacokinetics of gemcitabine and 2', 2'-difluorodeoxyuridine (dFdU, a…
To determine if SSA are effective in decreasing transfusion requirements and improving quality of life while being cost-effective.
To determine the effect of a high-fat meal on the exposure to docetaxel given as ModraDoc006 tablets in combination with ritonavir in patients with cancer.
The main objective is to investigate whether local mast cell activation correlates with an unstable phenotype of the atherosclerotic plaque.Secondary objectives are: 1. To investigate whether elevated systemic mast cell markers are correlated to…
Primary Objective:Efficacy:· Evaluate the efficacy of subcutaneous (sc) azacitidine in combination with durvalumab as compared with subcutaneous azacitidine alone in the defined study population.Secondary Objectives:Safety:· Assess the safety and…
To determine ex vivo neutrophil functions following exposure to therapeutic antibodies targeting inhibitory receptors expressed by neutrophils from RSV bronchiolitis patients. A secondary aim is to study soluble inhibitory receptors (such as LAIR-1…
Evaluating the effects of cognitive behavioral therapy for chronic insomnia (CBT-I) on sleep, general psychopathology, impulsivity and aggression in forensic psychiatric patients.
A multicenter randomized placebo controlled treatment study of leflunomide in polymyalgia rheumatica
This study has been transitioned to CTIS with ID 2024-514210-12-00 check the CTIS register for the current data. To investigate whether the use of leflunomide can prevent relapses during glucocorticoid tapering in patients with polymyalgia…
Develop and implement a new functional MRI protocol for function mapping in young children.
The objective of this study is to evaluate the safety and efficacy of the transapical and transfemoral JenaValve Pericardial TAVR System in treating subjects with symptomatic severe aortic stenosis or symptomatic severe aortic regurgitation…
To evaluate the safety and efficacy of extended dosing with volanesorsen (volanesorsen sodium 300 mg) in patients with FCS
The primary objective is to characterize the programming effects of Boston Scientific Vercise* PC System using the Deep Brain Stimulation Directional Lead for bilateral subthalamic nucleus DBS for the treatment of Parkinson*s disease in acute and…
The primary objective of this study is to investigate the accuracy and reliability of ultrasound scoliosis measurements and progression of the curve and to correlate these outcomes with the standard radiographic measurements obtained at the same…
Primary objective: To investigate the safety, tolerability and infectivity of male Schistosoma mansoni cercariae in healthy Schistosoma-naïve volunteers. Exploratory objectives: To investigate the kinetics of controlled infection with male…
This research project examines whether there are differences in effects between application of ImRs preceeded by CR and ImRs as a stand-alone treatment technique on the so-called encapsulated beliefs, cognitive beliefs based on the aversive…
The aim of the study is to gain insight, based on 30 N=1 trials, into whether intensive ESM monitoring can be used to evaluate the consequences of dose reduction of antipsychotic medication by detecting meaningful within-subject changes in daily…
The aim of this study is to investigate whether a smartphone app can increase physical activity in PDpatients for a long period of time (one year). The secondary aim is to test the potential effects of an increase in physical activity on physical…
Primary Objective: The aim of this study is to compare if an online consultation with diagnostic testing during a fertility workup, is as effective as a regular consultation in terms of patient centeredness, shared decision making and costs.
Gaining information on the dynamics and shape of the stent graft and stented target vessels, and how these change over time will improve our understanding about the fixation and/or sealing of the stent graft, which may help in stent graft selection…