841 results
Primary Objective:The primary objective is to assess the safety and tolerability of BMS-986179 administered alone and/or in combination with nivolumab.Secondary objectives:* To characterize the PD activity of BMS-986179 administered alone and in…
Primary objectives• To identify the percentage of patients in which a drug resistant clone can be detected with ctDNA before the emergence of radiological progression.• To determine the success rate of crizotinib and osimertinib combination…
This study has been transitioned to CTIS with ID 2024-511072-33-00 check the CTIS register for the current data. The aim is thereby to reduce the risk of serious infections and the need for regular CLL treatment.
Main objective:1. To estimate the Overall Response Rate (ORR) and the clinical benefit rate in selected cohorts of patients with hematologic malignancies,separately for each cohort2. To evaluate the safety of the selected dose regimes in an expanded…
The aim of this study is to improve our understanding of the development of late effects after cancer treatment and reveal potential targets for intervention/prevention. Therefore we will investigate mechanisms behind the early ageing phenotype…
Primary Objectives: - To evaluate the safety in mother and neonate/infant of nipocalimab administered to pregnant women at high risk for EOS-HDFN. - To evaluate the efficacy of nipocalimab as measured by proportion of patients with live birth at or…
The primary objective of this study is to explore the diagnostic accuracy of MRDTI in the diagnostic management of acute and chronic SVT in a prospective diagnostic proof of concept study. The secondary objectives include optimizing MRDTI sequences…
The objective of this study is to describe cognitive profile and dimensions of psychopathology in subjects with CNV disorders.
The primary objective of this trial is to evaluate quality of life outcomes in patients with CRLM during a patient-controlled follow-up approach. Secondary objectives are to evaluate anxiety, fear of cancer recurrence, survival, and the cost-…
We aim to identify diagnostic serum metabolite and protein biomarker signatures for early detection of cancer in asymptomatic high-risk population and prognostic biomarkers for selection of patients with poor prognosis.
- To establish the relationship between the use of deep neuromuscular blockade (NMB) with low pressure pneumoperitoneum (PNP) and the quality of recovery after RARP.- To establish the relationship between the use of deep neuromuscular blockade (NMB…
Our key objective of this study is to elucidate potential peripheral and central mechanisms that determine chronic pain characteristics in humans with OA.
The overall study aim is to determine the efficacy rate of complete ablation for the most promising types of thermal ablation (RFA, MWA or CA) technique for patients with early stage breast cancer (cT1N0M0) without an extensive component of DCIS (…
To evaluate and quantify the various clinical effects of closed-loop SCS versus open-loop SCS on the underlying pathophysiological effects in CRPS.
To assess the impact of CBT on treatment outcome after lumbar spinal fusion surgery in patients with high pain catastrophizing, a two-center randomized controlled trial comparing CBT care to education.
Primary Objective: To investigate the efficacy and safety of octreotide treatment (a somatostatin analogue) in decreasing the transfusion requirements (IV iron infusions and / or red blood cell transfusions) in patients with GI bleeding caused by…
The main goal of the current randomized study is to investigate if SABR may relieve tumor-related symptoms, improve the quality of life and potentially prolong survival in this frail patient group compared to best supportive care, which is the…
Primary objective:1. To assess the effect of 4 weeks SXB treatment on basal and cold-induced WAT lipolysis (assessed by levels of circulating free fatty acids) in narcolepsy type 1 patients. Secondary objectives:1. To assess the effects of 4 weeks…
The main objective of study 1 is to test whether psychological and psychophysiological indices of PC are differentially affected by fantasizing vs. mindfulness in a cross-over design in 50 remitted MDD patients vulnerable for depressive relapse. The…
In this study, we aim to improve survival to hospital discharge and costs/QALY in young patients with OHCA by decreasing the time in cardiac arrest by initiating ECPR on scene.