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Biobanking of testicular biopsies from azoospermic men undergoing testicular sperm extraction (TESE)

Biobanking of a testis biopsy from men with azoospermia who undergo a TESE procedure to allow investigation for understanding the etiology of male infertility, research about normal and aberrant male gamete formation in its natural environment of…

Language representation in children with 22q11 deletion syndrome and children with Specific Language Impairment

The main objective of this study is to determine the language representation in the brain of children with SLI and 22q11DS.

Subtyping of Insomnia

The primary objective of this study is to identify clinically relevant subtypes of insomnia using mainly physiological parameters. Mainly macro and microstructural parameters of the EEG will be used, as well as parameters from ECG and finger PPG.…

MR Imaging in Spinal Muscular Atrophy (SMA) as a biomarker for disease progression

To investigate the feasibility and usefulness of various MR techniques as a quantitative biomarker for SMA severity and disease progression. Two different MR protocols will be used. The first to investigate muscle tissue in the upper leg of both SMA…

Applied Public-Private Research enabling OsteoArthritis Clinical Headway study * a 2-year multicentre, European, exploratory study without therapeutic benefit in patients with knee osteoarthritis to describe, validate, and predict phenotypes of knee osteoarthritis by use of clinical, imaging, and biochemical (bio)markers.

To prospectively describe in detail pre-identified progressing phenotypes of patients with knee OA by use of conventional and novel clinical, imaging, and biochemical (bio)markers, and to validate and refine a predictive algorithm for these (and new…