16 results
PRIMARY OBJECTIVESthe assessment if survival in grade III glioma without combined 1p/19q loss is improved by - daily temozolomide chemotherapy during radiotherapy - the administration of temozolomide after the end of radiotherapy SECONDARY…
18-22 YEAR OLD MALES WIHT A NORMAL WEIGHTExamine the possible attenuating cardiometabolic health effects of (A) hourly, 10-min standing interruptions, when compared to a single bout of prolonged sitting, and (B) sitting on a stability ball, when…
The primary objective is investigating the effectiveness of *Mindlight* in treating (sub)clinical symptoms of anxiety in children who are diagnosed with an autism spectrum disorder. The secondary objective is to examine the factors that moderate and…
The objective of this study is to test the hypothesis that healthy obese pregnant women at increased risk for obesity-related pregnancy complications can be identified by a subgroup-specific screening program at twelve weeks amenorrhea.
From p12 of C1 protocol document:To assess how diurnal rates of muscle protein synthesis are altered during a short-term (3-day) implementation of resistance exercise training when compared to normal daily activity.
In the current study, we will 1) evaluate the usefulness and reliability of this new device, and 2) evaluate whether the anatomic site used will impact the measured CPM effect.
Recently, (changes in) the gut microbiome (flora / bacteria) have been associated with obesity and insulin resistance, and other cardiovascular risk factors or atherogenic processes. Venous thrombosis shares these risk factors, probably by a shared…
Aim of this study is to assess the effects of exercise intervention on breast cancer patients* quality of life on the short (6 months) and long-term (24 months) according to the cmRCT design and to test the utility of the cmRCT design in the field…
Primary: To assess whether the genetic architecture of this severe SCZ phenotype differs from the broad DSM-based SCZ phenotype.To predict response and side effects after clozapine intakeSecondary:1. To detect genetic associations with the current…
The objective of the induction/consolidation chemotherapy randomisation (R1) is to compare: - VIDE strategy: vincristine, ifosfamide, doxorubicin and etoposide (VIDE) as induction chemotherapy and vincristine, actinomycin D and ifosfamide (VAI),…
To investigate whether methylation patterns/levels and gene expression profiles predict treatment outcome after initiating CLZ.
This study has been transitioned to CTIS with ID 2024-518269-92-00 check the CTIS register for the current data. The objective of the study is to gather more information about the long-term effect of enzyme therapy in patients with Pompe disease…
To study whether polytherapy (methotrexate plus sulfasalazine plus hydroxychloroquine) results in more patients with inactive disease and therefore less patients who need treatment with a TNF inhibitor after 6 months of treatment compared to primary…
The current study aims to investigate whether vitamin and mineral status is associated with executive functioning in patients with an eating disorder. Key objectives: 1.To investigate the micronutrient status in patients with an eating disorder…
The purpose of the current investigation is therefore to prove the short-term equivalence and long-term benefit of the ABSORB scaffold over a Xience in patients at high risk of restenosis or with complex lesion(s).Diabetic substudyTo assess the…
This study has been transitioned to CTIS with ID 2024-516078-31-00 check the CTIS register for the current data. The objective of rEECur is to identify the optimum systemic anticancer regimen for recurrent and refractory Ewing sarcoma based on the…