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A randomized controlled multicenter phase III trial comparing cytoreductive surgery followed by intravenous chemotherapy versus intravenous chemotherapy alone for recurrent platinum-sensitive ovarian cancer

There is still no level I-II evidence for cytoreductive surgery in recurrent ovarian cancer. This is also the conclusion of a Cochrane Review of Galaal et al. published in June 2010. The most active chemotherapy in platinum sensitive recurrent…

Effects of dosing time on the pharmacokinetics and pharmacodynamics of sunitinib.

Primairy objective:To investigate whether the pharmacokinetics of sunitinib are influenced by circadian rhythm.Secondary objective:- to investigate whether daily variation in CYP3A4 activity exists in humans, based on midazolam and 4beta-…

Clinical and radiological evaluation of Signature* unicompartmental knee arthroplasty
A Prospective, Multi-centre, Randomized, Double blind study

Primary- To evaluate the initial and long-term clinical results in terms of function, quality of life and pain/satisfaction of the Signature* procedure compared to the standard operation instruments.- To evaluate the alignment of the Signature*…

Tinnitus suppression with electrical stimulation using cochlear implants (CI).

The main objective of the present study is to investigate the optimal stimulation pattern for tinnitus suppression in a structured way. Our study will focus on two parameters: stimulus level and anatomical stimulation site inside the cochlea.

Evaluation of bone metabolism in patients with ankylosing spondylitis

To study the relation between bone regulating and bone turnover markers and:a) bone mineral density measured by DEXAb) disease activity measured by BASDAI, ASAS response criteria and laboratory assessments (CRP and ESR)c) physical function measured…

Longitudinal Leiden Orthopaedics Outcomes of OsteoArthritis Study

Given the above mentioned gaps in knowledge, the aim of this project is to1) Describe the midterm and long-term outcomes of (primary and revision) total hip, total knee and shoulder replacement surgery in terms of health status as a whole, including…

International GBS Outcome Study
A prospective INC study on clinical and biological predictors of disease course en outcome in GBS

The International GBS Outcome Study (IGOS) aims to identify the most important clinical and biological determinants of disease progression and recovery in GBS. This information will be used to understand the diversity in clinical presentation and…

Fractional laser assisted photodynamic therapy in actinic keratosis: A pilot study

Objective is to perform a pilot study in order to assess wether a randomized controlled study can follow. This randomized study is necessary to proof effectiveness compared to regular photodynamic therapy. Objective is to present an effective and…

Development and Validation of Clinical Prediction Rules for Bleeding for Patients on Anticoagulant Therapy for Venous Thromboembolism.

General objective:To develop or validate a clinical prediction rule for major bleeding in patients on oral anticoagulant therapy (OAT) who have been safely anticoagulated without bleeding or venous thromboembolism (VTE) recurrence for 6 months since…