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The effect of perioperative (par)enteral nutrition on amino acid profile, cardiomyocytes functioning, and cardiac perfusion and metabolism of the cardiac surgical patient.

Our primary objective is to evaluate the effect of perioperative enteral and parenteral nutrition on amino acid profile and cardiomyocytes functioning in the cardiac surgical patient. Our secondary objective is to study the effect of the (par)…

A double-blind, randomised, placebo-controlled trial of prolonged antibiotic treatment after intravenous ceftriaxone in patients with (possible) persistent Lyme disease.

Prolonged antibiotic treatment of patients diagnosed with presumed PLD (as endorsed by the international ILADS guidelines) leads to better patient outcome than short-term treatment as endorsed by the Dutch CBO guidelines.

Real time vs. Flash glucose monitoring in type 1 diabetes - a cross-over trial

To compare the effects on glycemic control, patient reported outcomes (PRO) and experiences (PRE) of rt-CGM with FGM in a real-life outpatient setting among persons with T1D.

The reliability of the 13C-phenylalanine breath test for phenylketonuria patients: a pilot study

To establish the test-retest reliability of the 13C-PBT for measuring Phe hydroxylation in patients with PKU.

Synaptic density and tau pathology in Alzheimer's disease

This study has been transitioned to CTIS with ID 2024-517636-22-00 check the CTIS register for the current data. The main objective of the present study is to investigate the association between in vivo regional synaptic loss ([18F]SynVesT-1 PET),…

Hemodynamic Phenotype-Based, Capillary Refill Time-Targeted Resuscitation In Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial (A2)

To test if a CRT-targeted resuscitation based on clinical hemodynamic phenotyping can improve a hierarchical clinical outcome - mortality, time to cessation of vital organ support, and length of hospital stay, all within 28 days - in septic shock…

Binaural spatial enhancement study for cochlear implant users.

Determine speech understanding in noise with the AB*s bimodal BF directional hearing technology.

The effects of belimumab on synovial inflammation and composition of
lymph nodes in SLE patients

This study has been transitioned to CTIS with ID 2024-518966-28-00 check the CTIS register for the current data. The primary goal of this study is to investigate the effects of belimumab on the composition of lymph nodes and the inflamed synovial…

Search for Genetic Factors in Parkinson's Disease - II

The objectives of this study are: 1. to identify new genetic variants causing or predisposing to PD; 2. to characterize the clinical phenotype in PD associated to specific genetic variants; 3. to investigate the molecular mechanisms of PD in…

The effect of parenteral nutrition during nighttime versus daytime on bone turnover and energy metabolism in intestinal failure patients.

This study aims to determine the effect of nocturnal versus daytime cyclic infusion of parenteral nutrition in adult chronic intestinal failure patients on bone turnover, glucose metabolism, nitrogen balance, sleep and wake rhythm and clock genes…

The effect of mindfulness-based cognitive therapy on psychological distress in people with Parkinson*s Disease: clinical effects and cerebral mechanisms.

Test whether a mindfulness-based cognitive therapy intervention (MBCT) improves psychological distress, clinical symptoms, slows neurodegeneration, and/or enhances neuroplasticity in PD.

Treatment of severe gout patients with rasburicase

The primary outcome parameter is the Gout Activity Score (GAS)after 6 months of rasburicase treatment. Secondary outcome parameters are the serum uric acid concentration, the clinical evaluation of tophus load, patient reported outcomes: MD-HAQ, GAQ…

InvEstigation of the safety and perforMance of the NVT ALLEGRA THV System with a new delivery system in Patients with severe calcified aortIc stenosis or failed suRgical aortic bioprosthEsis

Confirm the technical performance of the new IMPERIA Delivery System and evaluate the safety and efficacy of the entire ALLEGRA THV System.

Evaluating the value of neuromechanical assessment in spasticity treatment

1. Evaluate the relation between pretreatment muscle weaknesses, spasticity, abnormal synergies, and changes in viscoelastic joint properties on the one hand, and changes in upper extremity spasticity following treatment on the other hand in…

Telemonitoring and E-Coaching in Hypertension

To determine the effects of the PCP+SM compared with usual care on BP control in adults with hypertension. To determine the effects of the PCP+SM compared with usual care on antihypertensive medication use in adults with hypertension. To determine…

Preventing recurrent *idiopathic* acute pancreatitis through laparoscopic cholecystectomy (PICUS-2):
a multicenter randomized trial

The goal of this trial is to determine the efficacy of LC in patients with IAP in the prevention of recurrent acute pancreatitis and biliary events. The secondary goal of this trial is to assess the occurrence of biliary events, complications of LC…

Biobank 3 Hoorn Diabetes Care System Cohort follow up 2023

To identify novel (causal) risk factors, including biomarkers and genetic determinants for disease progression and (severe) diabetes complications in people with T2D, in order to develop new, more targeted and effective therapies that will improve…

The Rainbow Study - A Randomized Controlled Trial to Evaluate the effect of Personalized Feedback on Symptom Perception in Asthmatic Children

Primary objective :How does measuring lung function and VAS at home with personalized feedback based on the Rainbow tool influence the perception of asthma related symptoms of asthmatic children? Secundary objectives: -Is there an additional effect…

Randomized multi-centre open-label non-inferiority phase 3 clinical trial for patients with a stage IV childhood renal tumour comparing upfront Vincristine, Actinomycin-D and Doxorubicin (VAD, standard arm) with upfront Vincristine, Carboplatin and Etoposide (VCE, experimental arm)

This study has been transitioned to CTIS with ID 2023-508926-91-00 check the CTIS register for the current data. To determine non-inferiority of preoperative 6 weeks of VCE to VAD in the overall metastatic rapid response rate (MetRR) in newly…

Dupuytren*s disease Evaluation of Preventative or Adjuvant Radiation Therapy

Primary objective: To show a meaningful reduction in progression of DD with the application of radiotherapy both in the early stages as well as following local treatment in the later stages.Secondary objectives: 1. Report physician graded toxicity…