164 results
Primary objective:To compare the efficacy of online hypnotherapy versus face-to-face according to a non-inferiority design for the treatment of IBS.Hypothesis: Hypnotherapy delivered in the form of online exercises has non-inferior efficacy to face-…
The primary objectives of this trial are:- To explore the pathomechanisms involved in the generation and healing of CD associated perianal fistulas- To understand the MoA of BI 655130 in patients with CD and draining perianal fistulas
The primary endpoint is the evaluation of the safety and toxicity of TIL with nivolumab and, thereafter, the safety and toxicity of the combination of PEG-IFNa, nivolumab plus TIL. Safety and toxicity will be evaluated according to CTCAE 4.0…
This study has been transitioned to CTIS with ID 2024-513897-23-00 check the CTIS register for the current data. The main objective of this study is to evaluate the use of molecular fluorescence imaging using cetuximab-IRDye800CW in the detection of…
The primary objective of this study is to confirm early and subtle MRI changes in PD patients which distinguish them from the healthy population and to create a diagnostic tool for neurologists based on these differences. Secondary objectives are to…
The aim of this study is to examine the effect of vitamin C supplementation on immune recovery in patients with autologous stem cell transplantation. The aim of the run-in phase of the study is to examine the effect of intravenous vitamin C…
The primary aim of this study is to investigate the feasibility of using UTC to detect differences in proximal hamstring tendon structure between individuals with and without clinically diagnosed PHT. A secondary aim is to: 1) investigate the within…
Primary goal: To evaluate the efficacy of alirocumab administered every 2 weeks (Q2W) versus placebo after 24 weeks of double-blind (DB) treatment on low-density lipoprotein cholesterol (LDL-C) levels in children with heterozygous familial…
This study has been transitioned to CTIS with ID 2024-517922-24-00 check the CTIS register for the current data. Although DC vaccinations have been used in allo-HCT settings, no previous studies have been performed using a CBDC vaccine after CBT.…
The primary objectives of this study are the following:* To prospectively characterize CEP290-related retinal degeneration and the clinical phenotype of participants with light perception to 20/50 visual acuity and with either compound heterozygous…
Our primary objective is to compare the effects of cyclic DBS with continuous DBS in OCD patients on 1) symptom severity. Secondary, we will compare the effects on 1) battery life 2) adverse events 3) cognitive performance 4) cortical EEG…
The purpose of this study is to evaluate the feasibility and efficiency of transducing freshly obtained CD34+ HSC from either mobilized peripheral blood or bone marrow of healthy donors using lentiviral SIN vectors encoding codon-optimized human…
Primary Objectives:Dose escalation (Part 1)Part 1A (SAR439459 monotherapy)-To determine the maximum tolerated dose (MTD) and/or maximum administered dose (MAD) of SAR439459 when administered intravenously as monotherapy in adult patients with…
Primary objectives - To evalulate the association between baseline tissue TMB/blood TMB and clinical efficacy (Objective Response Rate) for participants in Part 2- To evaluate the correlation between baseline tissue TMB and blood TMB for…
We will assess the (cost-)effectiveness of implementing two interventions in the birth centre setting:1. TcB measurement as a non-invasive screening tool to identify jaundice.2. Application of phototherapy in the birth centre.We hypothesise that…
The primary objective is to test the hypothesis that S-ICD implant without DFT with PRAETORIAN Score is non-inferior to S-ICD implant with DFT with regard to first shock efficacy in spontaneous events. The secondary objective is to evaluate the…
This study has been transitioned to CTIS with ID 2023-510200-42-00 check the CTIS register for the current data. Primary:• To show the superiority of norursodeoxycholic acid (norUDCA) compared to placebo in the treatment of Primary Sclerosing…
Primary: To determine whether three months of prophylactic treatment with co-trimoxazole causes a reduction in the number of days a child experiences at least two RTI symptoms in children aged 6 months to <=10 years with recurrent RTIs, when…
To study the metabolic fate of amino acids derived from muscle protein breakdown in septic patients.
Primary Objectives:To determine the efficacy of brigatinib, as evidenced by confirmed objective response rate (ORR), in patients with ALK+ locally advanced or metastatic NSCLC whose disease has progressed on therapy with alectinib or ceritinib.…