155 results
To determine the feasibility (main aim) and effectiveness (secondary aim) of a prehabilitation program in patients with HNC or liver cancer
This study has been transitioned to CTIS with ID 2024-512186-14-00 check the CTIS register for the current data. To assess benefits and harms of goal directed fluid removal with furosemide versus placebo on patient-important outcome measures in…
This study has been transitioned to CTIS with ID 2024-512616-21-00 check the CTIS register for the current data. The main objective of the trial is to determine the pathological response rate in cohort 1 and the radiological response rates in cohort…
The general objective of this study protocol is to add another follow-up measurement, round 8, to the Doetinchem cohort study, 6 years after round 7, and 36 years after round 1 This contributes to an infrastructure of data to tackle research…
The aim of this study is to assess whether the effectiveness of STN DBS for the treatment of Parkinson motor symptoms using imaging-based DBS programming is non-inferior compared to DBS programming with the current standard practice of clinical…
To assess the feasibility of a novel care program in which patients with a predicted mild course of acute pancreatitis are discharged early with remote home monitoring.
The main objective of the proposed study is to investigate the effect of PNS as a means to support the learning process in order to accelerate learning and improve knowledge and competence retention. This will be tested by applying PNS stimulation…
To assess the feasibility of using a subtherapeutic dose of piracetam as a marker of adherence to therapy by determining whether this subtherapeutic dose produces a detectable concentration in the urine
Primary Objective: Exploring peri-operative changes in microbiota composition between patient receiving oral antibiotics, oral antibiotics with amphotericin B or no oral prophylaxis, performed by 16S rRNA sequencing, analyzed by Microbiome Center…
Primary Objective: The performance in preventing intraoperative hypotension of a MAP treatment alarm of 72 mmHg compared to the performance of the HPI alarm. Secondary Objectives: - The correlation between the MAP signal and HPI signal - The…
In this research study we want to assess whether eating potato-rich food products are a good dietary strategy to recovery both liver and muscle glycogen stores following exhaustive exercise in healthy young endurance trained males over 24 hours.
This project aims to investigate peripheral and central neuroplasticity following an early (<13 weeks after injury) and intensive (8 weeks of 6 hours of additional therapy) upper extremity motor training program (EIUMT) aimed at recovery…
We aim to estimate the difference in effectiveness of DAS28CRP low disease activity and SDAI remission as treatment targets in RA treat to target strategies with regard to RA outcome.
To explore the effect of a LCHF diet on clinical symptoms and gut microbiome in MD patients due to the m.3243A>G mutation in mitochondrial DNA.
The aim of the present study is to investigate the effect of a citrus extract rich in the flavonoids hesperidin and naringin on sleep quality and mental wellbeing in healthy subjects with sleep (minor) disturbance.
The primary outcome of this study is the detection of clinical relevant adenomas (>= 5mm) in the ileal pouch.
In this study, we aim to investigate the possibility of FDG-PET/CT to reduce the number of (positive) SLNB procedures in patients with early stage oral squamous cell carcinoma and a clinically negative neck.
Primary objective: identifying biomarkers for response to filgotinib in patients with UC.Secondary objective: To establish a biobank which can be used for future inquiries into UC.
Evaluation of the fractional uptake rate (FUR) in 18F-FDG PET/CT to assess tumour metabolic activity
Primary objective: To investigate whether FDG PET quantification using the FUR is superior compared to the clinically used SUV.Secondary objectives: 1) To evaluate whether the metabolic tumor activity Km can be accurately asessed with 18F-FDG PET…
Primary objectiveThe primary objectives of this feasibility clinical investigation are to assess the overall usability of the Philips AirWaze investigational device as measured by the System Usability Score (SUS), and the accuracy of the tool-in-…