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Clear-Brain: A partial randomised clinical trial investigating stimulation of the glymphatic system by either deepening sleep with lower-sodium oxybate or inhibiting cortical spreading depressions with non-invasive vagus nerve stimulation, or both, in patients with Cerebral Amyloid Angiopathy (CAA).

Objectives:The main objective will be to assess whether treatment with nVNS, LXB or both interventions will increase the clearance of Aβ from the brain, compared to pre-treatment, in patients with CAA. Second objective is to study whether CAA…