30 results
This study aims at (further) revealing the pathophysiology of intestinal IR in man, with a specific interest for the role of proteases and protease-activated receptor-2 (PAR-2), cellular and inflammatory changes, barrier function and intestinal…
Studies examining the effect of couple therapy or couple-based interventions in treatment for personality disorder are very scarce and more research is required. Therefore, the present study examines the effect of couple-based interventions in…
The main objective is to examine the change in 68Ga-exendin tracer accumulation in the pancreas (i.e. beta cell mass) after RYGB by quantitative analysis of PET images before and one year after RYGB in morbid obese patients with type 2 diabetes.
The aim of the study is to compare transthoracic esophagectomy versus transhiatal extended gastrectomy in patients with GEJ type II tumors. It is hypothesized that esophagectomy allows for a higher rate of radical resections and a more complete…
To study the effect of voxelotor on the hemodynamics of the cerebral vasculature (CBF and CVR)
This study has been transitioned to CTIS with ID 2024-513186-39-00 check the CTIS register for the current data. Primary objective:To evaluate the efficacy of nivolumab in combination with ipilimumab in molecular pre-selected patients with…
This study has been transitioned to CTIS with ID 2022-502482-17-00 check the CTIS register for the current data. This study will evaluate the efficacy and safety of tiragolumab plus atezolizumab compared with placebo plus atezolizumab in patients…
This study has been transitioned to CTIS with ID 2024-511340-29-00 check the CTIS register for the current data. Primary Objective: Evaluate if testosterone replacement therapy (TRT) in (a)symptomatic testosterone deficient men with prostate cancer…
We want to compare the effectiveness of sclerotherapy and rubberband ligation when it comes to symptoms. We will secondarily consider patient satisfaction, complications and recurrences. We hypothesize that both treatments are equally effective.
Primary ObjectiveTo demonstrate that avelumab in combination with axitinib is superior to sunitinib monotherapy in prolonging PFS or OS in the first-line treatment of PD-L1 positive patients with aRCC.Secondary Objectives* To demonstrate that…
To assess achieved immunity against COVID-19 across the different age groups in The Netherlands by testing a representative part of the Dutch population for the presence of SARS-Cov-2 specific antibodies in serum
Primary Objective: Assess if the structure, composition and/or barrier function of the biliary HCO3- umbrella is intrinsically altered in cholangioids and liver biopsies derived from fibrosing cholangiopathy subjects compared to non-fibrosing…
To proof feasibility and safety of direct SEMS placement for palliative treatment of perihilar cholangiocarcinoma.
The objective of this study is to demonstrate that arthroscopic synovectomy of the wrist comined with deposition of intra-articular corticosteroids (DIACS) will lead to better functional outcomes compared to intra-articular corticosteroid injection…
The goal of this study is to investigate which treatment(-s) lead to the best outcome by using existing variation of practice.
This study has been transitioned to CTIS with ID 2023-505699-31-00 check the CTIS register for the current data. To evaluate the Long-Term Safety and Efficacy of upadacitinib.
To develop a pharmacokinetic (PK) model for the relationship between dosage, blood concentration and infection site concentration, estimating covariates to determine differences in antibiotic concentrations in synovial fluid, synovial tissue and…
The aim of this project is to identify biomarkers and novel therapeutic targets for pediatric Hodgkin lymphoma. To achieve this aim we defined three objectives:1.Hodgkin Reed-Sternberg cells: To perform whole exome sequencing and gene expression…
Phase 2 pilot-study: to examine feasible exercise dosages in patients with mCRC and collect data on preliminary effects on clinical outcomes.Phase 3 trial: to collect data on the efficacy of exercise on 1) chemotherapy dose modifications and 2)…
The primary aim of this study is to assess whether repetitive morning, daytime or pre-night spot urine sampling can accurately estimate dietary Na+ intake and to determine the number of spot urine collections that are needed. We will assess whether…