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EEG controlled triage in the ambulance for acute ischemic stroke

To determine the diagnostic accuracy of dry electrode cap EEG for diagnosis of LVO-a, when performed by paramedics in the ambulance in patients with a suspected AIS.

A 3-Part, Randomized, Double-Blind, Placebo-Controlled Phase 2 Study to Evaluate Safety and Efficacy of Avapritinib (BLU-285), a Selective KIT Mutation-Targeted Tyrosine Kinase Inhibitor, in Indolent and Smoldering Systemic Mastocytosis with Symptoms Inadequately Controlled with Standard Therapy

This study has been transitioned to CTIS with ID 2024-512585-34-00 check the CTIS register for the current data. Primary: Part 1 • To determine the RP2D of avapritinib in patients with ISM for use in Part 2 and Part 3 of the study.Part 2 • To…

A Phase 3 Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Upadacitinib in Adolescent and Adult Subjects with Moderate to Severe Atopic Dermatitis

This study has been transitioned to CTIS with ID 2022-502936-38-00 check the CTIS register for the current data. The objective of the study is to assess the efficacy and safety of upadacitinib for the treatment of adolescent and adult subjects with…

4D-IRECT Pilot Trial (4 Dimensional - Impairment of posttraumatic forearm Rotation Evaluated with Computed Tomography)

First, to develop a 4D computer-assisted diagnostic method for estimating the cause of posttraumatic impairment of the forearm. This method is intended to allow differentiation of motion patterns reflecting mutual impingement of radius and ulna from…

The effects of intra uterine exposure to Tumor Necrosis Factor alpha inhibitors in infants on the development of the immune system

Primary ObjectiveIn order to assess the effects of anti TNFα on the development of adaptive and innate immunity, children exposed to anti TNFα (with or without other immunosuppressive drugs) will be compared to children exposed to immunosuppressive…

A Multicenter, Open-label, Randomized, Phase 3 Trial to Compare the Efficacy and Safety of Lenvatinib in Combination with Everolimus or Pembrolizumab Versus Sunitinib Alone in First-Line Treatment of Subjects with Advanced Renal Cell Carcinoma (CLEAR).

The primary objective of the study is to demonstrate that lenvatinib in combination with everolimus (Arm A) or pembrolizumab (Arm B) is superior compared to sunitinib alone (Arm C) in improving progressionfree survival (PFS) (by independent imaging…

The influence of antipsychotic medication on dopamine D2 receptor availability. A [11C] raclopride PET study

The aim of the proposed study is to investigate the presence of dopaminergic abnormalities, as measured with [11C]raclopride, in relation to antipsychotic medication discontinuation in patients remitted after a first-episode psychosis (FEP).…

Measurement of Leakage of FFP2 Respirators and Surgical Masks in Human Volunteers

Primary Objective: Assess the leakage of FFP2 respirators and surgical masks in human subjects using inhalable aerosols consisting of a solution of fluorescein in water.Secondary Objective(s): (a) Study the variability in total inward leakage of…

NEW characterizing rate of progression in USHer syndrome (NEW-USH) study
a natural history study in patients with Usher syndrome

The study will help us to determine 1. the necessary type of (combined) examinations and 2. the sample size that is essential to evaluate (future) genetic therapy in Usher syndrome type 2 and USH2A associated nsRP.

Gene Environment interactions in Mental health trajectorieS of Youth (Youth-GEMS)

The objective of this study is to characterise and validate multidimensional latent risk and resilience mental health trajectories in a trans-syndromal sample of help-seeking young people, including identifying genetic, environmental, biological,…

Microbiome Intervention in Late-stage metastatic Lung cancer patients to improve response rate to immunotherapy

Investigate the effect of FMT from healthy obese donors on objective response rate (ORR according to RECIST criteria) in patients with metastasized or locally advanced NSCLC receiving standard of care first-line immunotherapy with or without…

Implantation of a non-diffractive extended depth-of-focus IOL and a monofocal IOL after myopic corneal laser refractive surgery: a randomized controlled trial.

The primary objective of this study is to compare the mean binocular DCIVA at 66 cm under photopic conditions 3 months after cataract surgery, in a series of patients, who previously underwent myopic laser surgery, bilaterally implanted with the non…

Developmental Outcome in Congenital Heart Disease in Kids

Primary Objective: To investigate motor developmental outcome at school age of children with CHD compared to typically developing peers.Secondary Objective(s): - To investigate neurodevelopmental outcom eat school age on several developmental…

68Ga-PSMA-PET/CT and genomic alterations for future selection of patients with metastatic castration resistant prostate cancer (mCRPC) for Radium-223 treatment.

Primary Objective: • To determine the clinical Progression Free Survival (cPFS) in our study cohort of patients with mCRPC and 68Ga-PSMA-PET/CT selected bone-only disease (PET-bone only group). The cPFS will be compared to the cPFS of patients with…

the effect of a MUsic intervention on poStictal agitation in Electroconvulsive therapy patients

The objective of the study is to assess the effect of music on postictal agitation when played peri-interventionally for patients undergoing electroconvulsive therapy for severe depression.

Navigation for percutaneous liver ablation

The primary aim of this study is to assess the feasibility of EM-navigation for percutaneous liver ablation.

The role of PF4-specific B cells in patients with Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT)

To enhance our knowledge of the molecular nature, induction and regulation of the autoantibody and B cell response involved in/responsible for the induction of VITT

Healthy ageing and intellectual disabilities (HA-ID) study

Gain insight into the health and health-related factors in adults with intellectual disabilities.

Hypothalamic damage in pediatric brain tumor survivors: Effects of Radiotherapy and associations with Cognitive functioning

Primary objective: Development of a normal tissue complication probability (NTCP) model for hypothalamic dysfunction (for severe hypothalamic dysfunction, named hypothalamic syndrome) in childhood brain tumor survivors, incorporating cranial…

*improving outcome of patients with squamous cell ESophageal CArcinoma by dose escaLATion using high-prEcision mr-guided radiotherapy (ESCALATE): a phase 1 dose finding trial*

The main objective of this study is to determine the maximum tolerated dose (MTD) of 2-fraction boost MRI-guided radiotherapy (MRgRT) for patients with SCC following CROSS therapy. The secondary objectives are feasibility, non-dose limiting toxicity…